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    kin-4 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 178068, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kin-4
    Official Full Name
    non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00002192
    Locus tag
    CELE_C10C6.1
    See related
    AllianceGenome:WB:WBGene00002192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Is expressed in head neurons; intestine; and tail neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108; female breast cancer; and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to several human genes including MAST1 (microtubule associated serine/threonine kinase 1) and MAST3 (microtubule associated serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kin-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    23
    Sequence:
    Chromosome: IV; NC_003282.8 (11425742..11447067)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PAN-3 domain-containing protein Neighboring gene Tyrosine-protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic screens identified dual roles of microtubule-associated serine threonine kinase and CREB within a single thermosensory neuron in the regulation of Caenorhabditis elegans thermotaxis behavior. Nakano S, et al. G3 (Bethesda), 2022 Nov 4. PMID 36102820, Free PMC Article
    2. A specificity map for the PDZ domain family. Tonikian R, et al. PLoS Biol, 2008 Sep 30. PMID 18828675, Free PMC Article
    3. KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. An SWA, et al. Aging Cell, 2019 Jun. PMID 30773781, Free PMC Article
    4. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Lehner B, et al. Nat Genet, 2006 Aug. PMID 16845399
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PDZ domain of KIN-4 binds PTEN, a key factor for the longevity of daf-2 mutants.
      Title: KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    non-specific serine/threonine protein kinase
    NP_001255551.1
    • Partially confirmed by transcript evidence
    NP_001255553.1
    • Partially confirmed by transcript evidence
    NP_001255554.1
    • Confirmed by transcript evidence
    NP_001255555.1
    • Partially confirmed by transcript evidence
    NP_001255556.1
    • Partially confirmed by transcript evidence
    NP_001255558.1
    • Confirmed by transcript evidence
    NP_001293977.1
    • Confirmed by transcript evidence
    NP_001366913.1
    • Confirmed by transcript evidence
    NP_001367231.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11425742..11447067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268627.2 → NP_001255556.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G331
      Conserved Domains (4) summary
      smart00220
      Location:816 → 1091
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1431 → 1518
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:815 → 1096
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:439 → 776
      DUF1908; Domain of unknown function (DUF1908)

    2. NM_001268622.2 → NP_001255551.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G328
      Conserved Domains (4) summary
      smart00220
      Location:819 → 1094
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1434 → 1521
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:818 → 1099
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:455 → 779
      DUF1908; Domain of unknown function (DUF1908)

    3. NM_001268624.3 → NP_001255553.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBW1
      Conserved Domains (4) summary
      smart00220
      Location:816 → 1091
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1431 → 1518
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:815 → 1096
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:452 → 776
      DUF1908; Domain of unknown function (DUF1908)

    4. NM_001380462.2 → NP_001366913.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFA4
      Conserved Domains (3) summary
      cd00992
      Location:1168 → 1255
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:552 → 833
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:189 → 513
      DUF1908; Domain of unknown function (DUF1908)

    5. NM_001380461.1 → NP_001367231.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG63
      Conserved Domains (3) summary
      cd00992
      Location:1399 → 1486
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:783 → 1064
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:420 → 744
      DUF1908; Domain of unknown function (DUF1908)

    6. NM_001268625.3 → NP_001255554.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G329
      Conserved Domains (4) summary
      smart00220
      Location:637 → 912
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1252 → 1339
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:636 → 917
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:273 → 597
      DUF1908; Domain of unknown function (DUF1908)

    7. NM_001268626.3 → NP_001255555.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255555.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G330
      Conserved Domains (4) summary
      smart00220
      Location:633 → 908
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1248 → 1335
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:632 → 913
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:269 → 593
      DUF1908; Domain of unknown function (DUF1908)

    8. NM_001307048.3 → NP_001293977.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKZ2
      Conserved Domains (4) summary
      smart00220
      Location:556 → 831
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1171 → 1258
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:555 → 836
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:179 → 516
      DUF1908; Domain of unknown function (DUF1908)

    9. NM_001268629.3 → NP_001255558.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255558.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3KFW7
      Conserved Domains (4) summary
      smart00220
      Location:370 → 645
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:985 → 1072
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:369 → 650
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:6 → 330
      DUF1908; Domain of unknown function (DUF1908)
    Nucleotide Protein
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