Prc1 protein regulator of cytokinesis 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prc1provided by MGI
Official Full Name: protein regulator of cytokinesis 1provided by MGI
Primary source: MGI:MGI:1858961
See related: Ensembl:ENSMUSG00000038943 AllianceGenome:MGI:1858961
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D7Ertd348e
Summary: Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to act upstream of or within microtubule bundle formation. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 31.2), liver E14 (RPKM 29.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D2; 7 45.62 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (79944224..79966007)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (80294445..80316259)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
Title: Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
Title: PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
Title: Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
Title: Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
Results indicate that Ub-independent mode of repression by PRC1 plays a key role in mammalian development during cell fate restriction.
Title: Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.
Authors analyzed whether elevated levels of the polycomb repressor complex 1 (PRC1) components Bmi1 and Ring1b and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.
Title: Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.
Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation.
Title: RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin.
Title: Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.
Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
Title: Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prc1 (e-PCR), detects polymorphism
- UniSTS:507172

RH127013 (e-PCR)
- UniSTS:167511

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokinesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within microtubule bundle formation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in contractile ring	ISO Inferred from Sequence Orthology more info
located_in contractile ring	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	ISO Inferred from Sequence Orthology more info	PubMed
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein regulator of cytokinesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285997.2 → NP_001272926.1 protein regulator of cytokinesis 1 isoform 2

See identical proteins and their annotated locations for NP_001272926.1

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

Consensus CDS

CCDS71985.1

UniProtKB/Swiss-Prot

E9QPF0, Q8CE25, Q99K43

UniProtKB/TrEMBL

G3XA79

Related

ENSMUSP00000043379.8, ENSMUST00000047558.14

Conserved Domains (2) summary

pfam03999
Location:37 → 598

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam13094
Location:34 → 130

CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
NM_001285998.2 → NP_001272927.1 protein regulator of cytokinesis 1 isoform 3

See identical proteins and their annotated locations for NP_001272927.1

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

Consensus CDS

CCDS71986.1

UniProtKB/TrEMBL

G3UY19, G3XA79

Related

ENSMUSP00000133910.2, ENSMUST00000173824.8

Conserved Domains (1) summary

pfam03999
Location:37 → 560

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001374624.1 → NP_001361553.1 protein regulator of cytokinesis 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (4).

Source sequence(s)

AC109232, AC136740

Consensus CDS

CCDS90258.1

UniProtKB/TrEMBL

G3UWQ7, G3XA79

Related

ENSMUSP00000133387.2, ENSMUST00000174172.8

Conserved Domains (1) summary

pfam03999
Location:37 → 615

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001382385.1 → NP_001369314.1 protein regulator of cytokinesis 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

UniProtKB/TrEMBL

G3XA79

Conserved Domains (1) summary

pfam03999
Location:37 → 549

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001382386.1 → NP_001369315.1 protein regulator of cytokinesis 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

UniProtKB/TrEMBL

G3XA79

Conserved Domains (1) summary

pfam03999
Location:1 → 496

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001382387.1 → NP_001369316.1 protein regulator of cytokinesis 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

UniProtKB/TrEMBL

G3XA79

Conserved Domains (1) summary

pfam03999
Location:37 → 517

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001382388.1 → NP_001369317.1 protein regulator of cytokinesis 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

UniProtKB/TrEMBL

G3XA79

Conserved Domains (1) summary

pfam03999
Location:37 → 612

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001382389.1 → NP_001369318.1 protein regulator of cytokinesis 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

UniProtKB/TrEMBL

G3XA79

Conserved Domains (1) summary

pfam03999
Location:37 → 614

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001382390.1 → NP_001369319.1 protein regulator of cytokinesis 1 isoform 10

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

UniProtKB/TrEMBL

G3XA79

Conserved Domains (1) summary

pfam03999
Location:1 → 440

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
NM_001420434.1 → NP_001407363.1 protein regulator of cytokinesis 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC109232, AC136740
NM_145150.4 → NP_660132.2 protein regulator of cytokinesis 1 isoform 1

See identical proteins and their annotated locations for NP_660132.2

Status: VALIDATED

Source sequence(s)

AC109232, AC136740

Consensus CDS

CCDS39998.2

UniProtKB/TrEMBL

G3UW86, G3XA79

Related

ENSMUSP00000129675.3, ENSMUST00000163812.9

Conserved Domains (2) summary

pfam03999
Location:37 → 601

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam13094
Location:34 → 130

CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit