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    • Showing Current items.

    ifet-1 Translational repressor ifet-1 [ Caenorhabditis elegans ]

    Gene ID: 175583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ifet-1
    Official Full Name
    Translational repressor ifet-1
    Primary source
    WormBase:WBGene00004132
    Locus tag
    CELE_F56F3.1
    See related
    AllianceGenome:WB:WBGene00004132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in negative regulation of translation. Located in P granule. Is expressed in gonad. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ifet-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (4471411..4475150, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like domain-containing protein Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein eS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. Sengupta MS, et al. J Cell Sci, 2013 Feb 1. PMID 23264733, Free PMC Article
    2. Regulation of maternal Wnt mRNA translation in C. elegans embryos. Oldenbroek M, et al. Development, 2013 Nov. PMID 24131629, Free PMC Article
    3. zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression. Guven-Ozkan T, et al. Development, 2010 Oct. PMID 20826530, Free PMC Article
    4. An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos. Li W, et al. J Cell Biol, 2009 Oct 5. PMID 19786575, Free PMC Article
    5. DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence. Fry AL, et al. PLoS Genet, 2021 Jul. PMID 34288923, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings suggest that IFET-1 is a key translational regulator and is required for normal P granule formation.
      Title: ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Translational repressor ifet-1
    NP_001369844.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4471411..4475150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001384075.2 → NP_001369844.1  Translational repressor ifet-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20898
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20898.2

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