cnnm-3 Metal transporter cnnm-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cnnm-3
Official Full Name: Metal transporter cnnm-3
Primary source: WormBase:WBGene00016343
Locus tag: CELE_C33D12.2
See related: AllianceGenome:WB:WBGene00016343
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; magnesium ion homeostasis; and positive regulation of vulval development. Located in basolateral plasma membrane. Is expressed in several structures, including intestine; nervous system; pharynx; rectum; and vulval muscle. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Orthologous to several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2); and CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cnnm-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 15

Sequence:: Chromosome: X; NC_003284.9 (3036427..3045847, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

he results revealed that RNAi-mediated inactivation of several genes restores gonad elongation, including aak-2, which encodes the catalytic subunit of AMP-activated protein kinase (AMPK). We then generated triple mutant worms for cnnm-1; cnnm-3; aak-2 and confirmed that the aak-2 mutation also suppressed the defective gonadal elongation in cnnm-1; cnnm-3 mutant worms.
Title: Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M02F4.8 (e-PCR)
- UniSTS:314690

C33D12.2 (e-PCR)
- UniSTS:313800

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	HEP more info	PubMed
involved_in magnesium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in magnesium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in magnesium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in magnesium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gonad development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to magnesium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Metal transporter cnnm-3

NP_001309670.1

Confirmed by transcript evidence

NP_001368594.1

Partially confirmed by transcript evidence

NP_001370534.1

Confirmed by transcript evidence

NP_001370952.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3036427..3045847 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322613.3 → NP_001309670.1 Metal transporter cnnm-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A131MBV5, A0A131MCZ8, A0A131MD56, Q21469

Conserved Domains (2) summary

pfam01595
Location:199 → 366

DUF21; Domain of unknown function DUF21

cl15354
Location:398 → 491

CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001383538.1 → NP_001370534.1 Metal transporter cnnm-3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl40423
Location:85 → 112

cupin_RmlC-like; RmlC-like cupin superfamily
NM_001383539.1 → NP_001370952.1 Metal transporter cnnm-3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

COG1253
Location:198 → 491

TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
NM_001380926.1 → NP_001368594.1 Metal transporter cnnm-3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl40423
Location:85 → 112

cupin_RmlC-like; RmlC-like cupin superfamily