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    FCGR2B Fc gamma receptor IIb [ Homo sapiens (human) ]

    Gene ID: 2213, updated on 27-Nov-2024

    Summary

    Official Symbol
    FCGR2Bprovided by HGNC
    Official Full Name
    Fc gamma receptor IIbprovided by HGNC
    Primary source
    HGNC:HGNC:3618
    See related
    Ensembl:ENSG00000072694 MIM:604590; AllianceGenome:HGNC:3618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcGRIIB; FcRII-c; FcgammaRIIb
    Summary
    The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
    Expression
    Biased expression in placenta (RPKM 92.9), appendix (RPKM 9.6) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FCGR2B in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161647243..161678654)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160991589..161022983)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161617033..161648444)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S23 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 4269 Neighboring gene Fc gamma receptor IIIb Neighboring gene ReSE screen-validated silencer GRCh37_chr1:161608151-161608340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1483 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161640790-161641368 Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1995 Neighboring gene Fc receptor like A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Malaria, susceptibility to
    MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
    Compare labs
    Systemic lupus erythematosus
    MedGen: C0024141 OMIM: 152700 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Nef nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables IgG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amyloid-beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables amyloid-beta binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables low-affinity IgG receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antibody-dependent cellular cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to amyloid-beta ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular response to molecule of bacterial origin ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cerebellum development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in defense response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in follicular B cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in follicular dendritic cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune complex clearance by monocytes and macrophages TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune effector process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immunoglobulin mediated immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT involved_in mast cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in mature B cell differentiation involved in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of B cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of acute inflammatory response to antigenic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of antibody-dependent cellular cytotoxicity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cytokine production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cytotoxic T cell degranulation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of dendritic cell antigen processing and presentation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of dendritic cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of humoral immune response mediated by circulating immunoglobulin ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of immunoglobulin production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of interleukin-10 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of macrophage activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of neutrophil activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of phagocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of type I hypersensitivity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of humoral immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of B cell antigen processing and presentation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of adaptive immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of dendritic spine maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of immune complex clearance by monocytes and macrophages TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor II-b
    Names
    CDw32
    Fc fragment of IgG receptor IIb
    Fc fragment of IgG, low affinity II, receptor for (CD32)
    Fc fragment of IgG, low affinity IIb, receptor (CD32)
    Fc fragment of IgG, low affinity IIb, receptor for (CD32)
    Fc gamma RIIb
    Fc-gamma RII-c
    Fc-gamma-RIIc
    IgG Fc receptor II-c
    Low affinity immunoglobulin gamma Fc region receptor II-c
    fc-gamma RII-b
    fc-gamma-RIIb
    fcRII-b
    igG Fc receptor II-b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023318.2 RefSeqGene

      Range
      20902..36413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002273.3NP_001002273.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor

      See identical proteins and their annotated locations for NP_001002273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL451067
      UniProtKB/Swiss-Prot
      O00523, O00524, O00525, P31995
      Conserved Domains (2) summary
      cd05752
      Location:49127
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:131213
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    2. NM_001002274.3NP_001002274.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 3 precursor

      See identical proteins and their annotated locations for NP_001002274.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL451067
      Consensus CDS
      CCDS30925.1
      UniProtKB/Swiss-Prot
      O00523, O00524, O00525, P31995
      Related
      ENSP00000236937.9, ENST00000236937.13
      Conserved Domains (2) summary
      cd05752
      Location:50128
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:132214
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    3. NM_001002275.3NP_001002275.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor

      See identical proteins and their annotated locations for NP_001002275.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AL451067
      UniProtKB/Swiss-Prot
      P31994
      Conserved Domains (2) summary
      cd05752
      Location:49127
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:131213
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    4. NM_001190828.2NP_001177757.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 5 precursor

      See identical proteins and their annotated locations for NP_001177757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL451067
      Consensus CDS
      CCDS53414.1
      UniProtKB/Swiss-Prot
      P31994
      Related
      ENSP00000356938.4, ENST00000367961.8
      Conserved Domains (3) summary
      cd05752
      Location:43121
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:125207
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:131207
      IG_like; Immunoglobulin like
    5. NM_001386000.1NP_001372929.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL451067
      Conserved Domains (2) summary
      cd05752
      Location:42120
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:124206
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    6. NM_001386001.1NP_001372930.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL451067
      Conserved Domains (2) summary
      cd05752
      Location:43121
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:125207
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    7. NM_001386002.1NP_001372931.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL451067
      Conserved Domains (2) summary
      cd05752
      Location:42120
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:124206
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    8. NM_001386003.1NP_001372932.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL451067
      Conserved Domains (2) summary
      cd05752
      Location:50128
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:132214
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    9. NM_001386004.1NP_001372933.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL451067
      Conserved Domains (2) summary
      cd05752
      Location:42120
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:124206
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    10. NM_001386005.1NP_001372934.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AL451067
      Conserved Domains (2) summary
      cd05752
      Location:50128
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:132214
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    11. NM_001386006.1NP_001372935.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AL451067
      Conserved Domains (2) summary
      cd05752
      Location:43121
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:125207
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    12. NM_001394477.1NP_001381406.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 14 encode the same isoform (1).
      Source sequence(s)
      AL451067
      Consensus CDS
      CCDS30924.1
      UniProtKB/Swiss-Prot
      A6H8N3, O95649, P31994, Q53X85, Q5VXA9, Q8NIA1
      Related
      ENSP00000351497.5, ENST00000358671.10
      Conserved Domains (2) summary
      cd05752
      Location:50128
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:132214
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    13. NM_004001.5NP_003992.3  low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

      See identical proteins and their annotated locations for NP_003992.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL451067
      Consensus CDS
      CCDS30924.1
      UniProtKB/Swiss-Prot
      A6H8N3, O95649, P31994, Q53X85, Q5VXA9, Q8NIA1
      Conserved Domains (2) summary
      cd05752
      Location:50128
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:132214
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    RNA

    1. NR_169827.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL451067

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161647243..161678654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454047.2XP_024309815.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X1

      Conserved Domains (2) summary
      cd05752
      Location:50128
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:132214
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160991589..161022983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335139.1XP_054191114.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X1