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    ZCWPW1 zinc finger CW-type and PWWP domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 55063, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZCWPW1provided by HGNC
    Official Full Name
    zinc finger CW-type and PWWP domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:23486
    See related
    Ensembl:ENSG00000078487 MIM:618900; AllianceGenome:HGNC:23486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZCW1
    Summary
    Enables histone reader activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 25.2), thyroid (RPKM 2.9) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZCWPW1 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100400872..100428703, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101640949..101668781, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99998495..100026326, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene STAG3L5P-PVRIG2P-PILRB readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26359 Neighboring gene paired immunoglobin like type 2 receptor beta Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99968027-99968778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26360 Neighboring gene paired immunoglobin like type 2 receptor alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26361 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99995395-99995894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100034207-100034710 Neighboring gene PPP1R35 antisense RNA 1 Neighboring gene methylphosphate capping enzyme Neighboring gene protein phosphatase 1 regulatory subunit 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots. Yuan S, et al. Genome Biol, 2022 Sep 6. PMID 36068616, Free PMC Article
    2. A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation. Song Y, et al. Reprod Health, 2024 Feb 3. PMID 38310235, Free PMC Article
    3. Structural insight into the zinc finger CW domain as a histone modification reader. He F, et al. Structure, 2010 Sep 8. PMID 20826339
    4. ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses. Gao Y, et al. Oncotarget, 2016 Apr 12. PMID 26958812, Free PMC Article
    5. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. Karch CM, et al. PLoS One, 2016. PMID 26919393, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation.
      Title: A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation.
    2. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
      Title: The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
    3. PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
      Title: PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
    4. ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.
      Title: ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.
    5. rs1476679 polymorphism in ZCWPW1 is associated with late-onset Alzheimer's disease.
      Title: ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses.
    6. PILRB and GATS expression levels, within the ZCWPW1 locus, were associated with Alzheimer's disease status.
      Title: Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.
    7. Of those 394 variants, 34 showed strong evidence of regulatory function (RegulomeDB score <3), and only 3 of them were genome-wide significant SNPs (ZCWPW1/rs1476679, CLU/rs1532278 and ABCA7/rs3764650).
      Title: Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10057, DKFZp434N0510

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in homologous chromosome pairing at meiosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiosis I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CW-type PWWP domain protein 1
    Names
    zinc finger CW-type and PWWP domain 1
    zinc finger, CW-type with PWWP domain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258008.3 → NP_001244937.1  zinc finger CW-type PWWP domain protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001244937.1

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Consensus CDS
      CCDS59067.1
      UniProtKB/Swiss-Prot
      Q9H0M4
      Related
      ENSP00000354210.4, ENST00000360951.8
      Conserved Domains (2) summary
      pfam07496
      Location:256 → 302
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:314 → 417
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    2. NM_001386008.1 → NP_001372937.1  zinc finger CW-type PWWP domain protein 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Conserved Domains (1) summary
      cl02554
      Location:85 → 155
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    3. NM_001386009.1 → NP_001372938.1  zinc finger CW-type PWWP domain protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      UniProtKB/TrEMBL
      A0A0S2Z5K5
      Conserved Domains (2) summary
      pfam07496
      Location:188 → 234
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:246 → 349
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    4. NM_001386010.1 → NP_001372939.1  zinc finger CW-type PWWP domain protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Consensus CDS
      CCDS94155.1
      UniProtKB/TrEMBL
      A0A804HK41, B4DXS7
      Related
      ENSP00000507762.1, ENST00000684423.1
      Conserved Domains (2) summary
      cd05837
      Location:314 → 417
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:256 → 302
      zf-CW; CW-type Zinc Finger

    5. NM_001386011.1 → NP_001372940.1  zinc finger CW-type PWWP domain protein 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Conserved Domains (2) summary
      pfam07496
      Location:125 → 171
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:183 → 286
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    6. NM_001386012.1 → NP_001372941.1  zinc finger CW-type PWWP domain protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      UniProtKB/TrEMBL
      B4DXS7
      Conserved Domains (2) summary
      cd05837
      Location:183 → 286
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:125 → 171
      zf-CW; CW-type Zinc Finger

    7. NM_001386013.1 → NP_001372942.1  zinc finger CW-type PWWP domain protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Conserved Domains (2) summary
      pfam07496
      Location:256 → 303
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:315 → 418
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    8. NM_001386015.1 → NP_001372944.1  zinc finger CW-type PWWP domain protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      UniProtKB/TrEMBL
      A0A0S2Z5J5
      Conserved Domains (2) summary
      cd05837
      Location:113 → 216
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:55 → 101
      zf-CW; CW-type Zinc Finger

    9. NM_001386016.1 → NP_001372945.1  zinc finger CW-type PWWP domain protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      UniProtKB/TrEMBL
      B4DXS7
      Conserved Domains (2) summary
      cd05837
      Location:314 → 417
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:256 → 302
      zf-CW; CW-type Zinc Finger

    10. NM_001386017.1 → NP_001372946.1  zinc finger CW-type PWWP domain protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      UniProtKB/TrEMBL
      B4DXS7
      Conserved Domains (2) summary
      cd05837
      Location:315 → 418
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:256 → 303
      zf-CW; CW-type Zinc Finger

    11. NM_001386018.1 → NP_001372947.1  zinc finger CW-type PWWP domain protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Conserved Domains (2) summary
      pfam07496
      Location:256 → 303
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:315 → 418
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    12. NM_001386019.1 → NP_001372948.1  zinc finger CW-type PWWP domain protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      UniProtKB/TrEMBL
      A0A0S2Z5K5
      Conserved Domains (2) summary
      pfam07496
      Location:188 → 234
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:246 → 349
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    13. NM_001386020.1 → NP_001372949.1  zinc finger CW-type PWWP domain protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Consensus CDS
      CCDS59067.1
      Conserved Domains (2) summary
      pfam07496
      Location:256 → 302
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:314 → 417
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    14. NM_001386021.1 → NP_001372950.1  zinc finger CW-type PWWP domain protein 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Conserved Domains (2) summary
      pfam07496
      Location:55 → 102
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:114 → 217
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    15. NM_001386022.1 → NP_001372951.1  zinc finger CW-type PWWP domain protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Conserved Domains (2) summary
      pfam07496
      Location:256 → 302
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:314 → 385
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    16. NM_001386023.1 → NP_001372952.1  zinc finger CW-type PWWP domain protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      UniProtKB/TrEMBL
      A0A0S2Z5E1
      Conserved Domains (2) summary
      pfam07496
      Location:188 → 235
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:247 → 350
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    17. NM_001388066.1 → NP_001374995.1  zinc finger CW-type PWWP domain protein 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    18. NM_017984.6 → NP_060454.3  zinc finger CW-type PWWP domain protein 1 isoform 1

      See identical proteins and their annotated locations for NP_060454.3

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849
      Consensus CDS
      CCDS43623.1
      UniProtKB/Swiss-Prot
      A8MVF5, B4DUQ2, Q8NA98, Q9BUD0, Q9H0M4, Q9NWF7
      UniProtKB/TrEMBL
      B4DXS7
      Related
      ENSP00000381109.2, ENST00000398027.6
      Conserved Domains (2) summary
      cd05837
      Location:313 → 416
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:256 → 301
      zf-CW; CW-type Zinc Finger

    RNA

    1. NR_169828.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    2. NR_169829.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    3. NR_169830.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    4. NR_169831.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    5. NR_169832.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    6. NR_169834.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    7. NR_169835.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    8. NR_169836.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    9. NR_169837.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    10. NR_169838.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    11. NR_169839.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005071, AC092849

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100400872..100428703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420554.1 → XP_047276510.1  zinc finger CW-type PWWP domain protein 1 isoform X10

    2. XM_006716038.5 → XP_006716101.1  zinc finger CW-type PWWP domain protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DXS7
      Conserved Domains (2) summary
      cd05837
      Location:314 → 417
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:256 → 302
      zf-CW; CW-type Zinc Finger

    3. XM_017012379.3 → XP_016867868.1  zinc finger CW-type PWWP domain protein 1 isoform X8

      Conserved Domains (2) summary
      pfam07496
      Location:256 → 302
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:314 → 385
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    4. XM_024446815.2 → XP_024302583.1  zinc finger CW-type PWWP domain protein 1 isoform X6

      UniProtKB/TrEMBL
      B4DXS7
      Conserved Domains (2) summary
      pfam07496
      Location:257 → 302
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:314 → 385
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    5. XM_005250480.4 → XP_005250537.1  zinc finger CW-type PWWP domain protein 1 isoform X7

      Conserved Domains (2) summary
      pfam07496
      Location:257 → 303
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:315 → 386
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    6. XM_006716040.5 → XP_006716103.1  zinc finger CW-type PWWP domain protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DXS7
      Conserved Domains (2) summary
      pfam07496
      Location:257 → 303
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:315 → 386
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    7. XM_006716035.5 → XP_006716098.1  zinc finger CW-type PWWP domain protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006716098.1

      UniProtKB/TrEMBL
      B4DXS7
      Conserved Domains (2) summary
      cd05837
      Location:315 → 418
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:257 → 303
      zf-CW; CW-type Zinc Finger

    8. XM_047420552.1 → XP_047276508.1  zinc finger CW-type PWWP domain protein 1 isoform X4

      UniProtKB/Swiss-Prot
      A8MVF5, B4DUQ2, Q8NA98, Q9BUD0, Q9H0M4, Q9NWF7
      UniProtKB/TrEMBL
      B4DXS7

    9. XM_047420553.1 → XP_047276509.1  zinc finger CW-type PWWP domain protein 1 isoform X6

      UniProtKB/TrEMBL
      B4DXS7

    10. XM_047420551.1 → XP_047276507.1  zinc finger CW-type PWWP domain protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A804HK41, B4DXS7

    11. XM_006716036.4 → XP_006716099.1  zinc finger CW-type PWWP domain protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006716099.1

      UniProtKB/TrEMBL
      B4DXS7
      Conserved Domains (2) summary
      cd05837
      Location:315 → 418
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      pfam07496
      Location:257 → 303
      zf-CW; CW-type Zinc Finger

    12. XM_024446817.2 → XP_024302585.1  zinc finger CW-type PWWP domain protein 1 isoform X9

      Conserved Domains (2) summary
      pfam07496
      Location:257 → 303
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:315 → 331
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101640949..101668781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358551.1 → XP_054214526.1  zinc finger CW-type PWWP domain protein 1 isoform X10

    2. XM_054358543.1 → XP_054214518.1  zinc finger CW-type PWWP domain protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DXS7

    3. XM_054358549.1 → XP_054214524.1  zinc finger CW-type PWWP domain protein 1 isoform X8

    4. XM_054358547.1 → XP_054214522.1  zinc finger CW-type PWWP domain protein 1 isoform X6

      UniProtKB/TrEMBL
      B4DXS7

    5. XM_054358548.1 → XP_054214523.1  zinc finger CW-type PWWP domain protein 1 isoform X7

    6. XM_054358545.1 → XP_054214520.1  zinc finger CW-type PWWP domain protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DXS7

    7. XM_054358541.1 → XP_054214516.1  zinc finger CW-type PWWP domain protein 1 isoform X1

      UniProtKB/TrEMBL
      B4DXS7

    8. XM_054358544.1 → XP_054214519.1  zinc finger CW-type PWWP domain protein 1 isoform X4

      UniProtKB/Swiss-Prot
      A8MVF5, B4DUQ2, Q8NA98, Q9BUD0, Q9H0M4, Q9NWF7
      UniProtKB/TrEMBL
      B4DXS7

    9. XM_054358546.1 → XP_054214521.1  zinc finger CW-type PWWP domain protein 1 isoform X6

      UniProtKB/TrEMBL
      B4DXS7

    10. XM_054358542.1 → XP_054214517.1  zinc finger CW-type PWWP domain protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A804HK41, B4DXS7

    11. XM_054358540.1 → XP_054214515.1  zinc finger CW-type PWWP domain protein 1 isoform X1

      UniProtKB/TrEMBL
      B4DXS7

    12. XM_054358550.1 → XP_054214525.1  zinc finger CW-type PWWP domain protein 1 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H0M4.2 GenPept UniProtKB/Swiss-Prot:Q9H0M4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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