mRNA-cap mRNA-capping-enzyme [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mRNA-capprovided by FlyBase
Official Full Name: mRNA-capping-enzymeprovided by FlyBase
Primary source: FLYBASE:FBgn0030556
Locus tag: Dmel_CG1810
See related: AllianceGenome:FB:FBgn0030556
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1810; Dmel\CG1810; PIR; RNGTT
Summary: Enables mRNA guanylyltransferase activity. Involved in 7-methylguanosine mRNA capping and positive regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Is expressed in adult head and organism. Orthologous to human RNGTT (RNA guanylyltransferase and 5'-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12E5-12E5; 1-48 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (14240266..14242822, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (14134299..14136855, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables mRNA 5'-triphosphate monophosphatase activity	IEA Inferred from Electronic Annotation more info
enables mRNA guanylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA guanylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mRNA guanylyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables mRNA guanylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in 7-methylguanosine mRNA capping	IEA Inferred from Electronic Annotation more info
involved_in 7-methylguanosine mRNA capping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mRNA-capping-enzyme

Names: CG1810-PA; mRNA capping enzyme; mRNA-cap-PA

NP_572952.1

EC 2.7.7.50

EC 3.1.3.-

EC 3.6.1.74

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

14240266..14242822 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132724.3 → NP_572952.1 mRNA-capping-enzyme [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572952.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VY44

Related

FBpp0073739

Conserved Domains (3) summary

pfam01331
Location:307 → 497

mRNA_cap_enzyme; mRNA capping enzyme, catalytic domain

pfam03919
Location:502 → 597

mRNA_cap_C; mRNA capping enzyme, C-terminal domain

cl21483
Location:116 → 171

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...