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    Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29713, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kcnj5provided by RGD
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 5provided by RGD
    Primary source
    RGD:61971
    See related
    EnsemblRapid:ENSRNOG00000033796 AllianceGenome:RGD:61971
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inward rectifier potassium channel activity and voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. Predicted to be involved in cardiac conduction; potassium ion import across plasma membrane; and regulation of monoatomic ion transmembrane transport. Located in T-tubule and external side of plasma membrane. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 183.1), Lung (RPKM 29.3) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnj5 in Genome Data Viewer
    Location:
    8q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (38981598..39011197, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30724923..30753083, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33435493..33463410, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480155 Neighboring gene Rho GTPase activating protein 32 Neighboring gene ribosomal protein L35 like 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene Fli-1 proto-oncogene, ETS transcription factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93525

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of I(KACh) inward rectifier potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G protein-activated inward rectifier potassium channel 4
    Names
    CIR
    GIRK-4
    GIRK4
    KATP-1
    cardiac inward rectifier
    heart KATP channel
    inward rectifier K(+) channel Kir3.4
    potassium channel, inwardly rectifying subfamily J member 5
    potassium voltage-gated channel subfamily J member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017297.2NP_058993.1  G protein-activated inward rectifier potassium channel 4

      See identical proteins and their annotated locations for NP_058993.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087022
      UniProtKB/Swiss-Prot
      P48548
      Related
      ENSRNOP00000048134.5, ENSRNOT00000041038.7
      Conserved Domains (2) summary
      pfam01007
      Location:54193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200371
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      38981598..39011197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080975.2XP_038936903.1  G protein-activated inward rectifier potassium channel 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G4T8
      Related
      ENSRNOP00000079101.1, ENSRNOT00000110676.2
      Conserved Domains (2) summary
      pfam01007
      Location:73212
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:219390
      IRK_C; Inward rectifier potassium channel C-terminal domain
    2. XM_039080976.2XP_038936904.1  G protein-activated inward rectifier potassium channel 4 isoform X3

      UniProtKB/Swiss-Prot
      P48548
      Conserved Domains (2) summary
      pfam01007
      Location:54193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200371
      IRK_C; Inward rectifier potassium channel C-terminal domain
    3. XM_039080977.2XP_038936905.1  G protein-activated inward rectifier potassium channel 4 isoform X3

      UniProtKB/Swiss-Prot
      P48548
      Conserved Domains (2) summary
      pfam01007
      Location:54193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200371
      IRK_C; Inward rectifier potassium channel C-terminal domain
    4. XM_063265036.1XP_063121106.1  G protein-activated inward rectifier potassium channel 4 isoform X3

      UniProtKB/Swiss-Prot
      P48548
    5. XM_063265035.1XP_063121105.1  G protein-activated inward rectifier potassium channel 4 isoform X1

      Related
      ENSRNOP00000099016.1, ENSRNOT00000159264.1