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    IntS4 Integrator 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IntS4provided by FlyBase
    Official Full Name
    Integrator 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0026679
    Locus tag
    Dmel_CG12113
    See related
    AllianceGenome:FB:FBgn0026679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12113; Dmel\CG12113; Int4; l(1)G0095
    Summary
    Involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human INTS4 (integrator complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IntS4 in Genome Data Viewer
    Location:
    7F4-7F4; 1-23 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8555239..8558781, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8449272..8452814, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ovarian tumor Neighboring gene Neuroglian Neighboring gene PIP82 Neighboring gene antisense RNA:CR46195 Neighboring gene uncharacterized protein Neighboring gene Topoisomerase related function 4-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inositol hexakisphosphate is required for Integrator function. Lin MH, et al. Nat Commun, 2022 Sep 30. PMID 36180473, Free PMC Article
    2. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
    3. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
    4. Female receptivity phenotype of icebox mutants caused by a mutation in the L1-type cell adhesion molecule neuroglian. Carhan A, et al. Genes Brain Behav, 2005 Nov. PMID 16268990
    5. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator 4
    Names
    CG12113-PA
    IntS4-PA
    lethal (1) G0095

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8555239..8558781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132260.3 → NP_572488.1  integrator 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W3E1
      Related
      FBpp0071178
      Conserved Domains (1) summary
      sd00044
      Location:432 → 459
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3E1.1 Q9W3E1

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