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    S2P membrane-bound transcription factor site-2 protease [ Drosophila erecta ]

    Gene ID: 6546958, updated on 15-May-2024

    Summary

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    Gene symbol
    S2P
    Gene description
    membrane-bound transcription factor site-2 protease
    Locus tag
    Dere_GG22629
    See related
    EnsemblRapid:LOC6546958
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Drosophila erecta
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    GG22629; GG22629-PA
    Orthologs
    fruit fly all
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    Genomic context

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    See S2P in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    101 current DereRS2 (GCF_003286155.1) Unplaced Scaffold NW_020825207.1 (4669216..4671330, complement)

    NW_020825207.1Genomic Context describing neighboring genes Neighboring gene guanine nucleotide-binding protein subunit beta-like protein 1 Neighboring gene Sine oculis-binding protein Neighboring gene LYR motif-containing protein 2 Neighboring gene uncharacterized LOC6546957 Neighboring gene monocarboxylic acid transporter silnoon

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_020825207 Unplaced Scaffold Reference DereRS2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of genes and genomes on the Drosophila phylogeny. Drosophila 12 Genomes Consortium, et al. Nature, 2007 Nov 8. PMID 17994087
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane protein intracellular domain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane-bound transcription factor site-2 protease
    Names
    Dere\GG22629
    Dere\GG22629-PA
    dere_GLEANR_7342

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Drosophila erecta Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference DereRS2

    Genomic

    1. NW_020825207.1 Reference DereRS2

      Range
      4669216..4671330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001975991.3 → XP_001976027.1  membrane-bound transcription factor site-2 protease

      See identical proteins and their annotated locations for XP_001976027.1

      UniProtKB/TrEMBL
      B3NSC5
      Related
      XP_001976027.1, XM_001975991.3
      Conserved Domains (2) summary
      COG0750
      Location:136 → 508
      RseP; Membrane-associated protease RseP, regulator of RpoE activity [Posttranslational modification, protein turnover, chaperones, Transcription]
      cl10020
      Location:6 → 218
      S2P-M50; Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic ...
    Nucleotide Protein
    Heading Accession and Version

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