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    Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) [ Mus musculus (house mouse) ]

    Gene ID: 24014, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnaselprovided by MGI
    Official Full Name
    ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)provided by MGI
    Primary source
    MGI:MGI:1098272
    See related
    Ensembl:ENSMUSG00000066800 AllianceGenome:MGI:1098272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E230029I04Rik
    Summary
    Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of D-glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in several structures, including brain and retina nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 11.6), CNS E11.5 (RPKM 9.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnasel in Genome Data Viewer
    Location:
    1 G3; 1 65.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153625089..153644441)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153749344..153768690)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C230024C17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:155593298-155593499 Neighboring gene STARR-positive B cell enhancer ABC_E5824 Neighboring gene STARR-positive B cell enhancer ABC_E9185 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155598826-155599127 Neighboring gene regulator of G-protein signaling 16 Neighboring gene regulator of G-protein signaling like 1 Neighboring gene predicted gene, 41974 Neighboring gene zinc finger protein 799 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Small self-RNA generated by RNase L amplifies antiviral innate immunity. Malathi K, et al. Nature, 2007 Aug 16. PMID 17653195, Free PMC Article
    2. Lack of RNase L attenuates macrophage functions. Yi X, et al. PLoS One, 2013. PMID 24324683, Free PMC Article
    3. Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity. Zhang R, et al. Proc Natl Acad Sci U S A, 2013 Aug 6. PMID 23878220, Free PMC Article
    4. Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L. Sorgeloos F, et al. PLoS Pathog, 2013. PMID 23825954, Free PMC Article
    5. Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus. Zhao L, et al. J Virol, 2013 Aug. PMID 23698313, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation.
      Title: Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation.
    2. A novel role of RNase L in the development of nonalcoholic steatohepatitis.
      Title: A novel role of RNase L in the development of nonalcoholic steatohepatitis.
    3. The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
      Title: The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
    4. Pref-1 mRNA is a novel substrate of RNase-L.
      Title: A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA.
    5. RNAse L stimulates fibroblast migration.
      Title: RNase L is a negative regulator of cell migration.
    6. Thus, activation of RNase L does not require mouse hepatitis virus virus-induced interferon but rather correlates with adequate levels of basal Oas gene expression, maintained by basal interferon signaling.
      Title: Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
    7. Thus, RNA cleavage events catalyzed by RNase L are required for optimal inflammasome activation during viral infections.
      Title: RNase L activates the NLRP3 inflammasome during viral infections.
    8. cellular functions of RNase L through protein-protein interactions in the spleen for immune response in mammals
      Title: Expression of mRNA and protein-protein interaction of the antiviral endoribonuclease RNase L in mouse spleen.
    9. Data indicate that deficiency of 2-5A-dependent RNase L (RNase L) in resulted in a significant delay of diabetes onset.
      Title: RNase L contributes to experimentally induced type 1 diabetes onset in mice.
    10. RNase L contributes to innate immunity through regulating macrophage functions.
      Title: Lack of RNase L attenuates macrophage functions.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    2-5A-dependent ribonuclease
    Names
    2-5A-dependent RNAase
    2-5A-dependent RNase
    RNase L
    ribonuclease 4
    NP_036012.1
    XP_006529590.1
    XP_006529591.1
    XP_011246295.1
    XP_030109810.1
    XP_030109811.1
    XP_030109813.1
    XP_036020559.1
    XP_036020560.1
    XP_036020561.1
    XP_036020562.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011882.2 → NP_036012.1  2-5A-dependent ribonuclease

      Status: VALIDATED

      Source sequence(s)
      AC154140, AK140815, BC138013
      Consensus CDS
      CCDS15377.1
      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Related
      ENSMUSP00000083385.4, ENSMUST00000086209.10
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      153625089..153644441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164669.1 → XP_036020562.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      S4R2R4
      Conserved Domains (5) summary
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl15368
      Location:588 → 680
      RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036164666.1 → XP_036020559.1  2-5A-dependent ribonuclease isoform X1

      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_036164667.1 → XP_036020560.1  2-5A-dependent ribonuclease isoform X1

      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Related
      ENSMUSP00000138752.2, ENSMUST00000183241.8
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_030253953.2 → XP_030109813.1  2-5A-dependent ribonuclease isoform X1

      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_030253950.2 → XP_030109810.1  2-5A-dependent ribonuclease isoform X1

      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_030253951.2 → XP_030109811.1  2-5A-dependent ribonuclease isoform X1

      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_006529528.5 → XP_006529591.1  2-5A-dependent ribonuclease isoform X1

      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_036164668.1 → XP_036020561.1  2-5A-dependent ribonuclease isoform X2

      UniProtKB/TrEMBL
      S4R2R4
      Conserved Domains (5) summary
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl15368
      Location:588 → 680
      RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_011247993.4 → XP_011246295.1  2-5A-dependent ribonuclease isoform X1

      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_006529527.5 → XP_006529590.1  2-5A-dependent ribonuclease isoform X1

      UniProtKB/Swiss-Prot
      Q05921, Q9ERU7
      UniProtKB/TrEMBL
      B2RQP1, S4UWW3
      Conserved Domains (5) summary
      cd10423
      Location:588 → 707
      RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
      sd00045
      Location:59 → 89
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:29 → 88
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:361 → 585
      PKc_like; Protein Kinases, catalytic domain
      cl39094
      Location:61 → 298
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05921.2 GenPept UniProtKB/Swiss-Prot:Q05921

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