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    Unc80 unc-80, NALCN activator [ Mus musculus (house mouse) ]

    Gene ID: 329178, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Unc80provided by MGI
    Official Full Name
    unc-80, NALCN activatorprovided by MGI
    Primary source
    MGI:MGI:2652882
    See related
    Ensembl:ENSMUSG00000055567 AllianceGenome:MGI:2652882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UNC-80; C030018G13Rik; C230061B10Rik
    Summary
    Predicted to enable monoatomic cation channel activity. Predicted to be involved in monoatomic cation homeostasis. Part of sodium channel complex. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 20.7), frontal lobe adult (RPKM 16.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Unc80 in Genome Data Viewer
    Location:
    1 C3; 1 33.56 cM
    Exon count:
    66
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66507093..66738309)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66467915..66699150)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 2 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01187 Neighboring gene STARR-seq mESC enhancer starr_01188 Neighboring gene predicted gene, 25411 Neighboring gene STARR-seq mESC enhancer starr_01189 Neighboring gene predicted gene, 39655 Neighboring gene STARR-seq mESC enhancer starr_01190 Neighboring gene STARR-seq mESC enhancer starr_01191 Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene STARR-positive B cell enhancer ABC_E5767 Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene predicted gene, 46093 Neighboring gene heat shock protein 1 (chaperonin) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception. Chen HW, et al. Int J Mol Sci, 2024 May 30. PMID 38892173, Free PMC Article
    2. Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Lu B, et al. Nature, 2009 Feb 5. PMID 19092807, Free PMC Article
    3. Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Wie J, et al. Nat Commun, 2020 Jul 3. PMID 32620897, Free PMC Article
    4. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Lu B, et al. Neuron, 2010 Nov 4. PMID 21040849, Free PMC Article
    5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception.
      Title: Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception.
    2. Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
      Title: Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
    3. Therefore, extracellular Ca(2+) influences neuronal excitability through the unc-79 homolog modifier of locomotor activity 3-UNC80-NALCN complex in a G protein-dependent fashion
      Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
    4. in the mouse hippocampal and ventral tegmental area neurons, substance P and neurotensin activate a channel complex containing NALCN and a large previously unknown protein UNC-80
      Title: Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AC118589.3

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of sodium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein unc-80 homolog
    Names
    NALCN channel associated protein
    unc-80 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368824.1 → NP_001355753.1  protein unc-80 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC091465, AC118589, AC131577
      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    2. NM_001368825.1 → NP_001355754.1  protein unc-80 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091465, AC118589, AC131577
      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    3. NM_175510.4 → NP_780719.2  protein unc-80 homolog isoform 2

      See identical proteins and their annotated locations for NP_780719.2

      Status: VALIDATED

      Source sequence(s)
      AC091465, AC118589, AC131577
      Consensus CDS
      CCDS48283.1
      UniProtKB/Swiss-Prot
      B2KGE8, B2KGG4, B8XCJ6, Q69Z93, Q8BJN5, Q8BLN6, Q8BLP6
      UniProtKB/TrEMBL
      A0A1D5RLV3
      Related
      ENSMUSP00000053692.10, ENSMUST00000061620.17
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      66507093..66738309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165856.1 → XP_036021749.1  protein unc-80 homolog isoform X19

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    2. XM_036165835.1 → XP_036021728.1  protein unc-80 homolog isoform X8

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    3. XM_036165837.1 → XP_036021730.1  protein unc-80 homolog isoform X10

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    4. XM_036165863.1 → XP_036021756.1  protein unc-80 homolog isoform X21

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    5. XM_036165809.1 → XP_036021702.1  protein unc-80 homolog isoform X1

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    6. XM_036165836.1 → XP_036021729.1  protein unc-80 homolog isoform X9

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    7. XM_036165841.1 → XP_036021734.1  protein unc-80 homolog isoform X12

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    8. XM_036165839.1 → XP_036021732.1  protein unc-80 homolog isoform X11

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    9. XM_036165844.1 → XP_036021737.1  protein unc-80 homolog isoform X13

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    10. XM_006496086.4 → XP_006496149.1  protein unc-80 homolog isoform X5

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    11. XM_036165847.1 → XP_036021740.1  protein unc-80 homolog isoform X14

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    12. XM_036165851.1 → XP_036021744.1  protein unc-80 homolog isoform X17

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    13. XM_036165810.1 → XP_036021703.1  protein unc-80 homolog isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    14. XM_036165824.1 → XP_036021717.1  protein unc-80 homolog isoform X6

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    15. XM_036165849.1 → XP_036021742.1  protein unc-80 homolog isoform X15

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Related
      ENSMUSP00000148517.2, ENSMUST00000212557.3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    16. XM_036165815.1 → XP_036021708.1  protein unc-80 homolog isoform X3

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    17. XM_036165850.1 → XP_036021743.1  protein unc-80 homolog isoform X16

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    18. XM_036165854.1 → XP_036021747.1  protein unc-80 homolog isoform X18

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    19. XM_036165816.1 → XP_036021709.1  protein unc-80 homolog isoform X4

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    20. XM_036165830.1 → XP_036021723.1  protein unc-80 homolog isoform X7

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    21. XM_036165859.1 → XP_036021752.1  protein unc-80 homolog isoform X20

      UniProtKB/TrEMBL
      A0A1D5RLV3
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    22. XM_036165864.1 → XP_036021757.1  protein unc-80 homolog isoform X22

    23. XM_036165866.1 → XP_036021759.1  protein unc-80 homolog isoform X23

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLN6.3 GenPept UniProtKB/Swiss-Prot:Q8BLN6

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