Nfe2l1 nuclear factor, erythroid derived 2,-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfe2l1provided by MGI
Official Full Name: nuclear factor, erythroid derived 2,-like 1provided by MGI
Primary source: MGI:MGI:99421
See related: Ensembl:ENSMUSG00000038615 AllianceGenome:MGI:99421
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NRF1; Lcrf1; TCF11; LCR-F1; TCF-11
Summary: This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in adrenal adult (RPKM 102.3), heart adult (RPKM 69.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 60.12 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96708239..96720810, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96817414..96829968, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice.
Title: Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice.
NFE2L1-mediated proteasome function protects from ferroptosis.
Title: NFE2L1-mediated proteasome function protects from ferroptosis.
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic beta-cell destruction and development of diabetes in male mice.
Title: Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Title: Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Synergism and Antagonism of Two Distinct, but Confused, Nrf1 Factors in Integral Regulation of the Nuclear-to-Mitochondrial Respiratory and Antioxidant Transcription Networks.
Title: Synergism and Antagonism of Two Distinct, but Confused, Nrf1 Factors in Integral Regulation of the Nuclear-to-Mitochondrial Respiratory and Antioxidant Transcription Networks.
The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models.
Title: The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models.
TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated macrophages through JNK signaling pathway.
Title: TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated macrophages through JNK signaling pathway.
Downregulation of miR4865p alleviates LPSinduced inflammatory injury, oxidative stress and apoptosis in Chondrogenic cell ATDC5 by targeting NRF1.
Title: Downregulation of miR‑486‑5p alleviates LPS‑induced inflammatory injury, oxidative stress and apoptosis in Chondrogenic cell ATDC5 by targeting NRF1.
Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARgamma expression.
Title: Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression.
Long-isoform NRF1 protects against arsenic cytotoxicity in mouse bone marrow-derived mesenchymal stem cells by suppressing mitochondrial ROS and facilitating arsenic efflux.
Title: Long-isoform NRF1 protects against arsenic cytotoxicity in mouse bone marrow-derived mesenchymal stem cells by suppressing mitochondrial ROS and facilitating arsenic efflux.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (8) 1 citation

General gene information

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Markers

UniSTS:274184 (e-PCR)
- UniSTS:274184

Nfe2l1 (e-PCR), detects polymorphism
- UniSTS:274184

RH124769 (e-PCR)
- UniSTS:161591

Nfe2l1 (e-PCR), detects polymorphism
- UniSTS:463421

AW212678 (e-PCR)
- UniSTS:180300

RH136041 (e-PCR)
- UniSTS:210036

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cholesterol binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cholesterol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to cholesterol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cysteine transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fructose 6-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose 6-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic metaphase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of odontoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of odontoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within regulation of proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: endoplasmic reticulum membrane sensor NFE2L1

Names: NF-E2-related factor 1; NFE2-related factor 1; locus control region-factor 1; nuclear factor erythroid 2-related factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130450.1 → NP_001123922.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 1

See identical proteins and their annotated locations for NP_001123922.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 5 encode the same isoform.

Source sequence(s)

AK038187, BC043063, CN527202

Consensus CDS

CCDS25304.1

UniProtKB/Swiss-Prot

E9Q038, O70234, Q61985

UniProtKB/TrEMBL

Q3U5L0, Q6GTN8

Related

ENSMUSP00000128527.2, ENSMUST00000167149.8

Conserved Domains (1) summary

cd14720
Location:620 → 687

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001130451.1 → NP_001123923.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 2

See identical proteins and their annotated locations for NP_001123923.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.

Source sequence(s)

AK038187, CJ144781, CJ152359

Consensus CDS

CCDS48893.1

UniProtKB/TrEMBL

Q3V3M1

Related

ENSMUSP00000131585.2, ENSMUST00000169828.8

Conserved Domains (1) summary

cd14720
Location:332 → 399

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001130452.1 → NP_001123924.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 2

See identical proteins and their annotated locations for NP_001123924.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.

Source sequence(s)

AK038187, CJ152359

Consensus CDS

CCDS48893.1

UniProtKB/TrEMBL

Q3V3M1

Conserved Domains (1) summary

cd14720
Location:332 → 399

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001130453.1 → NP_001123925.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK038187, AK148471, CF163519

Consensus CDS

CCDS48894.1

UniProtKB/TrEMBL

Q3UFI8, Q3V3M1

Related

ENSMUSP00000127804.2, ENSMUST00000167110.8

Conserved Domains (1) summary

cd14720
Location:462 → 529

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001130454.1 → NP_001123926.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 4

See identical proteins and their annotated locations for NP_001123926.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK038187, AK148471

UniProtKB/TrEMBL

Q3UFI8

Conserved Domains (1) summary

cd14720
Location:451 → 518

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001361682.1 → NP_001348611.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 5

Status: VALIDATED

Source sequence(s)

AK038187, AL596384, CF163519, CJ151652

Conserved Domains (1) summary

cd14720
Location:493 → 560

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_008686.3 → NP_032712.2 endoplasmic reticulum membrane sensor NFE2L1 isoform 1

See identical proteins and their annotated locations for NP_032712.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 5 encode the same isoform.

Source sequence(s)

AK038187, AK152040, BC043063, BY301848

Consensus CDS

CCDS25304.1

UniProtKB/Swiss-Prot

E9Q038, O70234, Q61985

UniProtKB/TrEMBL

Q3U5L0, Q6GTN8

Related

ENSMUSP00000080467.6, ENSMUST00000081775.12

Conserved Domains (1) summary

cd14720
Location:620 → 687

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

96708239..96720810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156406.1 → XP_036012299.1 endoplasmic reticulum membrane sensor NFE2L1 isoform X4

Conserved Domains (1) summary

cd14720
Location:324 → 391

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
XM_036156405.1 → XP_036012298.1 endoplasmic reticulum membrane sensor NFE2L1 isoform X3

UniProtKB/TrEMBL

Q3V3M1

Conserved Domains (1) summary

cd14720
Location:332 → 399

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
XM_036156403.1 → XP_036012296.1 endoplasmic reticulum membrane sensor NFE2L1 isoform X1

UniProtKB/TrEMBL

Q3U5L0

Conserved Domains (1) summary

cd14720
Location:567 → 634

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
XM_036156404.1 → XP_036012297.1 endoplasmic reticulum membrane sensor NFE2L1 isoform X2

Conserved Domains (1) summary

cd14720
Location:440 → 507

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain