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    Daam1 dishevelled associated activator of morphogenesis 1 [ Mus musculus (house mouse) ]

    Gene ID: 208846, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Daam1provided by MGI
    Official Full Name
    dishevelled associated activator of morphogenesis 1provided by MGI
    Primary source
    MGI:MGI:1914596
    See related
    Ensembl:ENSMUSG00000034574 AllianceGenome:MGI:1914596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in Wnt signaling pathway and presynaptic actin cytoskeleton organization. Located in perinuclear region of cytoplasm and stress fiber. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and gut. Used to study intrinsic cardiomyopathy. Orthologous to human DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.5), whole brain E14.5 (RPKM 8.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Daam1 in Genome Data Viewer
    Location:
    12 30.06 cM; 12 C3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71877834..72039150)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (71830950..71992376)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630002D21 gene Neighboring gene STARR-seq mESC enhancer starr_32425 Neighboring gene predicted gene, 46356 Neighboring gene STARR-seq mESC enhancer starr_32426 Neighboring gene STARR-seq mESC enhancer starr_32427 Neighboring gene UPF0538 protein C2orf76 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_32428 Neighboring gene STARR-positive B cell enhancer ABC_E5334 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_32431 Neighboring gene predicted gene, 53214 Neighboring gene predicted gene, 40440

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility. Nishimura T, et al. J Cell Biol, 2016 Nov 21. PMID 27807130, Free PMC Article
    2. Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Colozza G, et al. Sci Adv, 2023 Nov 24. PMID 38000028, Free PMC Article
    3. The formin Daam1 and fascin directly collaborate to promote filopodia formation. Jaiswal R, et al. Curr Biol, 2013 Jul 22. PMID 23850281, Free PMC Article
    4. Localization of the Diaphanous-related formin Daam1 to neuronal dendrites. Salomon SN, et al. Neurosci Lett, 2008 Dec 5. PMID 18832009
    5. Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network. Luo W, et al. PLoS One, 2016. PMID 27760153, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
      Title: WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
    2. we generated Daam-deficient mice by gene targeting and found that Daam1, but not Daam2, is necessary for fetal survival. Embryonic development of Daam1 mutants was delayed most likely due to functional defects in the labyrinthine layer of the placenta. Examination of Daam2 and Daam1/2 double mutants revealed that Daam1 and Daam2 are functionally redundant during placental development.
      Title: Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2.
    3. MTSS1's C terminus binds to DAAM1 and paused DAAM1-mediated F-actin polymerization.
      Title: MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells.
    4. The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression.
      Title: Daam1 regulates fascin for actin assembly in mouse oocyte meiosis.
    5. DAAM1 organizes actin filaments into a nodal complex
      Title: Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network.
    6. DAAM1 loss evokes invasive abilities of epithelial cells.
      Title: DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility.
    7. Daam1 knockout mice that were also homozygous for Daam2 had stronger noncompaction cardiomyopathy, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation.
      Title: DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
    8. Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles.
      Title: The formin Daam1 and fascin directly collaborate to promote filopodia formation.
    9. Daam1 is important for regulating filamentous actin assembly and organization, and consequently for cytoskeletal function in cardiomyocytes, which contributes to proper heart morphogenesis.
      Title: Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
    10. a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1
      Title: Mechanism of activation of the Formin protein Daam1.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA0666, E130308H01, 1700066F09Rik, 2310028E21Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in presynaptic actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disheveled-associated activator of morphogenesis 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286452.1 → NP_001273381.1  disheveled-associated activator of morphogenesis 1 isoform b

      See identical proteins and their annotated locations for NP_001273381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AC159186, AK033683, AK147480, AK162231, BC076585
      Consensus CDS
      CCDS88349.1
      UniProtKB/TrEMBL
      Q6ZQ74
      Related
      ENSMUSP00000152532.2, ENSMUST00000221317.2
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam02181
      Location:600 → 973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_001422845.1 → NP_001409774.1  disheveled-associated activator of morphogenesis 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC124356, AC159186

    3. NM_001422846.1 → NP_001409775.1  disheveled-associated activator of morphogenesis 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC124356, AC159186

    4. NM_026102.3 → NP_080378.2  disheveled-associated activator of morphogenesis 1 isoform a

      See identical proteins and their annotated locations for NP_080378.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC124356, AK033683, AK162231, BC076585, CD352113
      Consensus CDS
      CCDS25964.1
      UniProtKB/Swiss-Prot
      Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
      UniProtKB/TrEMBL
      Q6ZQ74
      Related
      ENSMUSP00000082406.3, ENSMUST00000085299.4
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    5. NM_172464.3 → NP_766052.2  disheveled-associated activator of morphogenesis 1 isoform a

      See identical proteins and their annotated locations for NP_766052.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC124356, AK033683, AK162231, BC076585
      Consensus CDS
      CCDS25964.1
      UniProtKB/Swiss-Prot
      Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
      UniProtKB/TrEMBL
      Q6ZQ74
      Related
      ENSMUSP00000152564.2, ENSMUST00000223272.2
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      71877834..72039150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246636.1 → XP_030102496.1  disheveled-associated activator of morphogenesis 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
      UniProtKB/TrEMBL
      Q6ZQ74
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. XM_036157296.1 → XP_036013189.1  disheveled-associated activator of morphogenesis 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
      UniProtKB/TrEMBL
      Q6ZQ74
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. XM_036157297.1 → XP_036013190.1  disheveled-associated activator of morphogenesis 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
      UniProtKB/TrEMBL
      Q6ZQ74
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain

    4. XM_006515642.4 → XP_006515705.1  disheveled-associated activator of morphogenesis 1 isoform X1

      See identical proteins and their annotated locations for XP_006515705.1

      UniProtKB/Swiss-Prot
      Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
      UniProtKB/TrEMBL
      Q6ZQ74
      Conserved Domains (4) summary
      PRK12704
      Location:444 → 513
      PRK12704; phosphodiesterase; Provisional
      pfam06367
      Location:235 → 439
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:600 → 982
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:45 → 232
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPM0.4 GenPept UniProtKB/Swiss-Prot:Q8BPM0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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