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    Rbfox1 RNA binding protein, fox-1 homolog (C. elegans) 1 [ Mus musculus (house mouse) ]

    Gene ID: 268859, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rbfox1provided by MGI
    Official Full Name
    RNA binding protein, fox-1 homolog (C. elegans) 1provided by MGI
    Primary source
    MGI:MGI:1926224
    See related
    Ensembl:ENSMUSG00000008658 AllianceGenome:MGI:1926224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A2bp; A2bp1; fox-1; Hrnbp1
    Summary
    Enables mRNA 3'-UTR binding activity. Acts upstream of or within neuromuscular process controlling balance; regulation of alternative mRNA splicing, via spliceosome; and regulation of skeletal muscle cell differentiation. Located in cytoplasm and nucleus. Is expressed in central nervous system; cranial nerve; heart; peripheral nervous system ganglion; and retina. Orthologous to human RBFOX1 (RNA binding fox-1 homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 4.4), cortex adult (RPKM 3.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbfox1 in Genome Data Viewer
    Location:
    16 A1; 16 3.34 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (5702566..7230344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5884793..7412480)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41414 Neighboring gene STARR-seq mESC enhancer starr_39960 Neighboring gene STARR-seq mESC enhancer starr_39962 Neighboring gene predicted gene, 41416 Neighboring gene STARR-positive B cell enhancer mm9_chr16:5709155-5709456 Neighboring gene STARR-seq mESC enhancer starr_39963 Neighboring gene RIKEN cDNA 1700123O21 gene Neighboring gene STARR-seq mESC enhancer starr_39966 Neighboring gene predicted gene, 52234 Neighboring gene predicted gene, 36902 Neighboring gene STARR-seq mESC enhancer starr_39967 Neighboring gene STARR-seq mESC enhancer starr_39968 Neighboring gene predicted gene, 53933 Neighboring gene predicted gene, 52235 Neighboring gene STARR-seq mESC enhancer starr_39969 Neighboring gene predicted gene, 36824 Neighboring gene STARR-seq mESC enhancer starr_39971 Neighboring gene STARR-seq mESC enhancer starr_39973 Neighboring gene STARR-seq mESC enhancer starr_39974 Neighboring gene STARR-seq mESC enhancer starr_39975 Neighboring gene STARR-seq mESC enhancer starr_39977 Neighboring gene STARR-seq mESC enhancer starr_39978 Neighboring gene STARR-seq mESC enhancer starr_39979 Neighboring gene STARR-seq mESC enhancer starr_39984 Neighboring gene STARR-seq mESC enhancer starr_39985 Neighboring gene STARR-seq mESC enhancer starr_39987 Neighboring gene STARR-seq mESC enhancer starr_39988 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:7419874-7419983 Neighboring gene STARR-seq mESC enhancer starr_39989 Neighboring gene STARR-seq mESC enhancer starr_39990 Neighboring gene STARR-seq mESC enhancer starr_39991 Neighboring gene STARR-seq mESC enhancer starr_39992 Neighboring gene STARR-seq mESC enhancer starr_39993 Neighboring gene STARR-seq mESC enhancer starr_39994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:7767895-7768078 Neighboring gene STARR-seq mESC enhancer starr_39996 Neighboring gene STARR-seq mESC enhancer starr_39998 Neighboring gene STARR-seq mESC enhancer starr_39999 Neighboring gene predicted gene, 29854 Neighboring gene STARR-seq mESC enhancer starr_40001 Neighboring gene STARR-seq mESC enhancer starr_40002 Neighboring gene predicted gene, 26159

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Visual Function and Survival of Injured Retinal Ganglion Cells in Aged Rbfox1 Knockout Animals. Gu L, et al. Cells, 2022 Oct 27. PMID 36359797, Free PMC Article
    2. Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development. Hamada N, et al. Sci Rep, 2016 Aug 2. PMID 27481563, Free PMC Article
    3. Developmental expression mapping of a gene implicated in multiple neurodevelopmental disorders, A2bp1 (Fox1). Hammock EA, et al. Dev Neurosci, 2011. PMID 21346316, Free PMC Article
    4. Rbfox1 Is Expressed in the Mouse Brain in the Form of Multiple Transcript Variants and Contains Functional E Boxes in Its Alternative Promoters. Casanovas S, et al. Front Mol Neurosci, 2020. PMID 32431595, Free PMC Article
    5. An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons. Lee JA, et al. Genes Dev, 2009 Oct 1. PMID 19762510, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Visual Function and Survival of Injured Retinal Ganglion Cells in Aged Rbfox1 Knockout Animals.
      Title: Visual Function and Survival of Injured Retinal Ganglion Cells in Aged Rbfox1 Knockout Animals.
    2. Transcriptional regulation of the thymus master regulator Foxn1.
      Title: Transcriptional regulation of the thymus master regulator Foxn1.
    3. Rbfox1 expression in amacrine cells is restricted to GABAergic and VGlut3 glycinergic cells.
      Title: Rbfox1 expression in amacrine cells is restricted to GABAergic and VGlut3 glycinergic cells.
    4. Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNAbinding protein RBFOX1 in this disease.
      Title: Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease.
    5. Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models.
      Title: Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models.
    6. The authors found that upregulation of Rbfox1, an RNA binding protein associated with intellectual disability, epilepsy and autism, increases selectively hippocampal TrkB.T1 isoform expression. Physiologically, increased Rbfox1 impairs BDNF-dependent LTP which can be rescued by genetically restoring TrkB.T1 levels.
      Title: Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels.
    7. Rbfox deletion did not cause a reduction in global protein synthesis, but it led to altered splicing of hundreds of gene transcripts, including capn3, which produced an active form of calpain3 protease.
      Title: Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.
    8. The data imply Rbfox1 may be involved in the development of cardiomyopathies via regulating the alternative splicing of CaV1.2 exon 33.
      Title: Characterization of Ca(V)1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and Ca(V)1.2 exon 33 expressions in human heart failure.
    9. Rbfox1 is a regulator in the development of cortical interneuron-subtype-specific efferent connectivity.
      Title: Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons.
    10. The regulation of interneuron-specific Vamp1 by Rbfox1 contributes to performance of specialized functions in defined neuronal subtypes.
      Title: Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA binding protein fox-1 homolog 1
    Names
    ataxin 2 binding protein 1
    fox-1 homolog A
    hexaribonucleotide binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359723.2 → NP_001346652.1  RNA binding protein fox-1 homolog 1 isoform gamma

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (gamma), compared to isoform 1.
      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654
      Consensus CDS
      CCDS37245.1
      UniProtKB/Swiss-Prot
      Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
      UniProtKB/TrEMBL
      A0A2R8VK79
      Related
      ENSMUSP00000155069.3, ENSMUST00000230658.3
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:252 → 341
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    2. NM_001359724.2 → NP_001346653.1  RNA binding protein fox-1 homolog 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (1).
      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:252 → 338
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    3. NM_001359725.2 → NP_001346654.1  RNA binding protein fox-1 homolog 1 isoform gamma

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in both UTR's and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (gamma), compared to isoform 1.
      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654, AC164097
      Consensus CDS
      CCDS37245.1
      UniProtKB/Swiss-Prot
      Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
      UniProtKB/TrEMBL
      A0A2R8VK79
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:252 → 341
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    4. NM_001359726.2 → NP_001346655.1  RNA binding protein fox-1 homolog 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654
      Conserved Domains (3) summary
      cd12407
      Location:140 → 215
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:249 → 337
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl27169
      Location:48 → 145
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    5. NM_001359728.2 → NP_001346657.1  RNA binding protein fox-1 homolog 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654
      UniProtKB/TrEMBL
      A0A2R8VK79
      Conserved Domains (3) summary
      cd12407
      Location:140 → 215
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:276 → 365
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl27169
      Location:48 → 145
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    6. NM_001359729.2 → NP_001346658.1  RNA binding protein fox-1 homolog 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in both UTR's and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (4), compared to isoform 1.
      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654
      UniProtKB/TrEMBL
      A0A2R8VK79, A0AAQ4VMR5
      Related
      ENSMUSP00000159958.1, ENSMUST00000249862.1
      Conserved Domains (3) summary
      cd12407
      Location:140 → 215
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:276 → 364
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl27169
      Location:48 → 145
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    7. NM_001359730.2 → NP_001346659.1  RNA binding protein fox-1 homolog 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has multiple coding region differences, compared to variant 4. This results in a shorter isoform (5), compared to isoform 1.
      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654
      UniProtKB/TrEMBL
      A0A2R8VK79
      Conserved Domains (3) summary
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:252 → 341
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl27169
      Location:4 → 121
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    8. NM_001417334.1 → NP_001404263.1  RNA binding protein fox-1 homolog 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
      UniProtKB/TrEMBL
      A0AAQ4VMS4
      Related
      ENSMUSP00000159975.1, ENSMUST00000249878.1

    9. NM_001417335.1 → NP_001404264.1  RNA binding protein fox-1 homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    10. NM_001417336.1 → NP_001404265.1  RNA binding protein fox-1 homolog 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654

    11. NM_001417337.1 → NP_001404266.1  RNA binding protein fox-1 homolog 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    12. NM_001417338.1 → NP_001404267.1  RNA binding protein fox-1 homolog 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC161378, AC163654

    13. NM_001417339.1 → NP_001404268.1  RNA binding protein fox-1 homolog 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC161378, AC163654
      UniProtKB/TrEMBL
      A0AAQ4VMX8
      Related
      ENSMUSP00000160018.1, ENSMUST00000249920.1

    14. NM_001417340.1 → NP_001404269.1  RNA binding protein fox-1 homolog 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654

    15. NM_001417341.1 → NP_001404270.1  RNA binding protein fox-1 homolog 1 isoform gamma

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
      UniProtKB/Swiss-Prot
      Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
      Related
      ENSMUSP00000049970.9, ENSMUST00000056416.9

    16. NM_001417342.1 → NP_001404271.1  RNA binding protein fox-1 homolog 1 isoform gamma

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
      UniProtKB/Swiss-Prot
      Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
      Related
      ENSMUSP00000111507.4, ENSMUST00000115841.10

    17. NM_001417343.1 → NP_001404272.1  RNA binding protein fox-1 homolog 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654

    18. NM_001417344.1 → NP_001404273.1  RNA binding protein fox-1 homolog 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654

    19. NM_001417345.1 → NP_001404274.1  RNA binding protein fox-1 homolog 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC154705, AC161378, AC163654

    20. NM_001417376.1 → NP_001404305.1  RNA binding protein fox-1 homolog 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    21. NM_001417377.1 → NP_001404306.1  RNA binding protein fox-1 homolog 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

    22. NM_001417379.1 → NP_001404308.1  RNA binding protein fox-1 homolog 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    23. NM_001417380.1 → NP_001404309.1  RNA binding protein fox-1 homolog 1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654

    24. NM_001417381.1 → NP_001404310.1  RNA binding protein fox-1 homolog 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
      Related
      ENSMUSP00000155799.3, ENSMUST00000231088.3

    25. NM_001417382.1 → NP_001404311.1  RNA binding protein fox-1 homolog 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654, AC164097

    26. NM_001417383.1 → NP_001404312.1  RNA binding protein fox-1 homolog 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    27. NM_001417384.1 → NP_001404313.1  RNA binding protein fox-1 homolog 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

    28. NM_001417385.1 → NP_001404314.1  RNA binding protein fox-1 homolog 1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC161378, AC163654

    29. NM_001417386.1 → NP_001404315.1  RNA binding protein fox-1 homolog 1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC161378, AC163654
      Related
      ENSMUSP00000155321.2, ENSMUST00000231194.2

    30. NM_001417387.1 → NP_001404316.1  RNA binding protein fox-1 homolog 1 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC154705, AC161378, AC163654

    31. NM_001417388.1 → NP_001404317.1  RNA binding protein fox-1 homolog 1 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    32. NM_001417389.1 → NP_001404318.1  RNA binding protein fox-1 homolog 1 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
      Related
      ENSMUSP00000159957.1, ENSMUST00000249861.1

    33. NM_001417390.1 → NP_001404319.1  RNA binding protein fox-1 homolog 1 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

    34. NM_001417391.1 → NP_001404320.1  RNA binding protein fox-1 homolog 1 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654

    35. NM_001417392.1 → NP_001404321.1  RNA binding protein fox-1 homolog 1 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC154705, AC161378, AC163654

    36. NM_001417393.1 → NP_001404322.1  RNA binding protein fox-1 homolog 1 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    37. NM_001417394.1 → NP_001404323.1  RNA binding protein fox-1 homolog 1 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    38. NM_001417395.1 → NP_001404324.1  RNA binding protein fox-1 homolog 1 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    39. NM_001417396.1 → NP_001404325.1  RNA binding protein fox-1 homolog 1 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

    40. NM_001417398.1 → NP_001404327.1  RNA binding protein fox-1 homolog 1 isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654

    41. NM_001417399.1 → NP_001404328.1  RNA binding protein fox-1 homolog 1 isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    42. NM_001417400.1 → NP_001404329.1  RNA binding protein fox-1 homolog 1 isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

    43. NM_001417403.1 → NP_001404332.1  RNA binding protein fox-1 homolog 1 isoform 29

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC161378, AC163654

    44. NM_001417404.1 → NP_001404333.1  RNA binding protein fox-1 homolog 1 isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC161378, AC163654

    45. NM_001417405.1 → NP_001404334.1  RNA binding protein fox-1 homolog 1 isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    46. NM_001417406.1 → NP_001404335.1  RNA binding protein fox-1 homolog 1 isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

    47. NM_001417407.1 → NP_001404336.1  RNA binding protein fox-1 homolog 1 isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

    48. NM_001417408.1 → NP_001404337.1  RNA binding protein fox-1 homolog 1 isoform 32

      Status: VALIDATED

      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

    49. NM_001417409.1 → NP_001404338.1  RNA binding protein fox-1 homolog 1 isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC124225, AC161378, AC163654

    50. NM_021477.6 → NP_067452.2  RNA binding protein fox-1 homolog 1 isoform gamma

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in both UTR's and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (gamma), compared to isoform 1.
      Source sequence(s)
      AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654, AC164097
      Consensus CDS
      CCDS37245.1
      UniProtKB/Swiss-Prot
      Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
      UniProtKB/TrEMBL
      A0A2R8VK79
      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:252 → 341
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    51. NM_183188.3 → NP_899011.2  RNA binding protein fox-1 homolog 1 isoform alpha

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in both UTR's and has multiple coding region differences, compared to 4 . This results in a shorter isoform (alpha), compared to isoform 1.
      Source sequence(s)
      AC122000, AC124225, AC161378, AC163654
      Consensus CDS
      CCDS27936.1
      UniProtKB/TrEMBL
      A0A2R8VK79
      Related
      ENSMUSP00000155364.2, ENSMUST00000229741.2
      Conserved Domains (3) summary
      COG0724
      Location:82 → 219
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:136 → 211
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:272 → 362
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      5702566..7230344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522179.4 → XP_006522242.1  RNA binding protein fox-1 homolog 1 isoform X21

      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:252 → 341
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    2. XM_036159945.1 → XP_036015838.1  RNA binding protein fox-1 homolog 1 isoform X31

      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:225 → 311
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    3. XM_036159943.1 → XP_036015836.1  RNA binding protein fox-1 homolog 1 isoform X30

      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:225 → 312
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    4. XM_036159933.1 → XP_036015826.1  RNA binding protein fox-1 homolog 1 isoform X15

      Conserved Domains (3) summary
      PRK03427
      Location:40 → 157
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:288 → 374
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:152 → 227
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    5. XM_036159939.1 → XP_036015832.1  RNA binding protein fox-1 homolog 1 isoform X25

      UniProtKB/TrEMBL
      A0A2R8VK79
      Conserved Domains (3) summary
      PRK03427
      Location:40 → 157
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:288 → 377
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:152 → 227
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    6. XM_006522173.5 → XP_006522236.1  RNA binding protein fox-1 homolog 1 isoform X14

      Conserved Domains (3) summary
      PRK03427
      Location:40 → 157
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:152 → 227
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:288 → 377
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    7. XM_036159936.1 → XP_036015829.1  RNA binding protein fox-1 homolog 1 isoform X20

      Conserved Domains (3) summary
      PRK03427
      Location:40 → 157
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:261 → 347
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:152 → 227
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    8. XM_036159941.1 → XP_036015834.1  RNA binding protein fox-1 homolog 1 isoform X27

      UniProtKB/TrEMBL
      A0A2R8VI79, A0A2R8VK79
      Conserved Domains (3) summary
      PRK03427
      Location:40 → 157
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:261 → 350
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:152 → 227
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    9. XM_036159935.1 → XP_036015828.1  RNA binding protein fox-1 homolog 1 isoform X19

      Conserved Domains (3) summary
      PRK03427
      Location:40 → 157
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:261 → 348
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:152 → 227
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    10. XM_011245907.4 → XP_011244209.2  RNA binding protein fox-1 homolog 1 isoform X2

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:379 → 467
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    11. XM_017316989.3 → XP_017172478.2  RNA binding protein fox-1 homolog 1 isoform X8

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:379 → 468
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    12. XM_006522155.5 → XP_006522218.3  RNA binding protein fox-1 homolog 1 isoform X1

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:379 → 468
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    13. XM_011245915.4 → XP_011244217.2  RNA binding protein fox-1 homolog 1 isoform X9

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:379 → 468
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    14. XM_011245914.4 → XP_011244216.2  RNA binding protein fox-1 homolog 1 isoform X7

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:379 → 469
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    15. XM_011245910.4 → XP_011244212.2  RNA binding protein fox-1 homolog 1 isoform X3

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:379 → 469
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    16. XM_017316988.3 → XP_017172477.2  RNA binding protein fox-1 homolog 1 isoform X6

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:352 → 440
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    17. XM_030249123.2 → XP_030104983.1  RNA binding protein fox-1 homolog 1 isoform X12

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:352 → 441
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    18. XM_011245912.4 → XP_011244214.2  RNA binding protein fox-1 homolog 1 isoform X5

      Conserved Domains (3) summary
      PRK03427
      Location:131 → 248
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:243 → 318
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:352 → 441
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    19. XM_006522178.4 → XP_006522241.1  RNA binding protein fox-1 homolog 1 isoform X21

      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:252 → 341
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    20. XM_036159946.1 → XP_036015839.1  RNA binding protein fox-1 homolog 1 isoform X31

      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:225 → 311
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    21. XM_036159944.1 → XP_036015837.1  RNA binding protein fox-1 homolog 1 isoform X30

      Conserved Domains (3) summary
      PRK03427
      Location:4 → 121
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:225 → 312
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:116 → 191
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    22. XM_030249125.1 → XP_030104985.1  RNA binding protein fox-1 homolog 1 isoform X17

      Conserved Domains (3) summary
      PRK03427
      Location:48 → 145
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:140 → 215
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:276 → 364
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    23. XM_006522175.5 → XP_006522238.1  RNA binding protein fox-1 homolog 1 isoform X16

      Conserved Domains (3) summary
      PRK03427
      Location:48 → 145
      PRK03427; cell division protein ZipA; Provisional
      cd12407
      Location:140 → 215
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:276 → 365
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    24. XM_036159938.1 → XP_036015831.1  RNA binding protein fox-1 homolog 1 isoform X24

      Conserved Domains (3) summary
      PRK03427
      Location:48 → 145
      PRK03427; cell division protein ZipA; Provisional
      pfam12414
      Location:249 → 336
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:140 → 215
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJ43.3 GenPept UniProtKB/Swiss-Prot:Q9JJ43

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