Wdr47 WD repeat domain 47 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr47provided by MGI
Official Full Name: WD repeat domain 47provided by MGI
Primary source: MGI:MGI:2139593
See related: Ensembl:ENSMUSG00000040389 AllianceGenome:MGI:2139593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0893; 1810073M12Rik
Summary: Acts upstream of or within several processes, including detection of hot stimulus involved in thermoception; neuronal stem cell population maintenance; and telencephalon development. Located in several cellular components, including growth cone; microtubule; and neuronal cell body. Is expressed in several structures, including central nervous system; pancreas; respiratory system; sensory organ; and vibrissa. Orthologous to human WDR47 (WD repeat domain 47). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 32.5), CNS E14 (RPKM 23.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F3; 3 47.38 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (108498302..108553035)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (108591223..108645719)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules.
Title: Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules.
we identify a novel LisH/WD40 repeat protein, tentatively named nemitin (neuronal enriched MAP interacting protein), as a potential regulator of MAP8-associated microtubule function
Title: Nemitin, a novel Map8/Map1s interacting protein with Wd40 repeats.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124515 (e-PCR)
- UniSTS:161337

RH139348 (e-PCR)
- UniSTS:221434

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior commissure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex radial glia-guided migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of hot stimulus involved in thermoception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD repeat-containing protein 47

Names: nemitin; neuronal enriched MAP interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358053.1 → NP_001344982.1 WD repeat-containing protein 47 isoform 2

Status: VALIDATED

Source sequence(s)

AL683823

Conserved Domains (4) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

cd00200
Location:599 → 915

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:611 → 659

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
NM_001358054.1 → NP_001344983.1 WD repeat-containing protein 47 isoform 3

Status: VALIDATED

Source sequence(s)

AL683823

Conserved Domains (5) summary

smart00667
Location:9 → 42

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

cd00200
Location:600 → 868

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:612 → 660

7WD40; WD40 repeat [structural motif]

cl26927
Location:293 → 483

Activator_LAG-3; Transcriptional activator LAG-3
NM_001358055.1 → NP_001344984.1 WD repeat-containing protein 47 isoform 3

Status: VALIDATED

Source sequence(s)

AL683823

Conserved Domains (5) summary

smart00667
Location:9 → 42

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

cd00200
Location:600 → 868

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:612 → 660

7WD40; WD40 repeat [structural motif]

cl26927
Location:293 → 483

Activator_LAG-3; Transcriptional activator LAG-3
NM_181400.3 → NP_852065.2 WD repeat-containing protein 47 isoform 1

See identical proteins and their annotated locations for NP_852065.2

Status: VALIDATED

Source sequence(s)

AL683823

Consensus CDS

CCDS17765.1

UniProtKB/Swiss-Prot

A2AGC7, Q80TP4, Q8CGF6

Related

ENSMUSP00000057482.9, ENSMUST00000051145.15

Conserved Domains (5) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

pfam11498
Location:293 → 483

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:600 → 916

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:612 → 660

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

108498302..108553035

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502415.5 → XP_006502478.1 WD repeat-containing protein 47 isoform X9

See identical proteins and their annotated locations for XP_006502478.1

Conserved Domains (5) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

pfam11498
Location:300 → 490

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:607 → 925

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:619 → 667

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_006502414.5 → XP_006502477.1 WD repeat-containing protein 47 isoform X9

See identical proteins and their annotated locations for XP_006502477.1

Conserved Domains (5) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

pfam11498
Location:300 → 490

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:607 → 925

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:619 → 667

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_036163436.1 → XP_036019329.1 WD repeat-containing protein 47 isoform X10

Conserved Domains (4) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

cd00200
Location:607 → 923

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:619 → 667

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_006502417.5 → XP_006502480.1 WD repeat-containing protein 47 isoform X11

Conserved Domains (5) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

pfam11498
Location:293 → 483

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:600 → 918

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:612 → 660

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_011240310.3 → XP_011238612.1 WD repeat-containing protein 47 isoform X12

Conserved Domains (5) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

pfam11498
Location:293 → 482

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:599 → 917

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:611 → 659

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_017319818.3 → XP_017175307.1 WD repeat-containing protein 47 isoform X9

Conserved Domains (5) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

pfam11498
Location:300 → 490

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:607 → 925

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:619 → 667

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_011240309.3 → XP_011238611.1 WD repeat-containing protein 47 isoform X10

Conserved Domains (4) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

cd00200
Location:607 → 923

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:619 → 667

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_030252938.2 → XP_030108798.1 WD repeat-containing protein 47 isoform X11

Conserved Domains (5) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

pfam11498
Location:293 → 483

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:600 → 918

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:612 → 660

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_017319819.2 → XP_017175308.1 WD repeat-containing protein 47 isoform X13

UniProtKB/Swiss-Prot

A2AGC7, Q80TP4, Q8CGF6

Conserved Domains (5) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

pfam11498
Location:293 → 483

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:600 → 916

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:612 → 660

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_036163437.1 → XP_036019330.1 WD repeat-containing protein 47 isoform X14

Conserved Domains (4) summary

smart00668
Location:45 → 102

CTLH; C-terminal to LisH motif

cd00200
Location:599 → 915

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:611 → 659

7WD40; WD40 repeat [structural motif]

pfam17814
Location:13 → 40

LisH_TPL; LisH-like dimerisation domain
XM_030252937.2 → XP_030108797.1 WD repeat-containing protein 47 isoform X8

Conserved Domains (5) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

pfam11498
Location:343 → 532

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:649 → 965

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:661 → 709

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain
XM_030252939.2 → XP_030108799.1 WD repeat-containing protein 47 isoform X15

Conserved Domains (5) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

pfam11498
Location:350 → 540

Activator_LAG-3; Transcriptional activator LAG-3

sd00039
Location:668 → 715

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain

cl29593
Location:657 → 756

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030252932.1 → XP_030108792.1 WD repeat-containing protein 47 isoform X1

Conserved Domains (5) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

pfam11498
Location:350 → 540

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:657 → 975

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:669 → 717

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain
XM_030252933.2 → XP_030108793.1 WD repeat-containing protein 47 isoform X3

Conserved Domains (5) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

pfam11498
Location:350 → 540

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:657 → 973

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:669 → 717

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain
XM_011240308.2 → XP_011238610.2 WD repeat-containing protein 47 isoform X2

Conserved Domains (5) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

pfam11498
Location:350 → 539

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:656 → 974

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:668 → 716

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain
XM_036163435.1 → XP_036019328.1 WD repeat-containing protein 47 isoform X4

Conserved Domains (4) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

cd00200
Location:656 → 972

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:668 → 716

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain
XM_030252934.1 → XP_030108794.1 WD repeat-containing protein 47 isoform X5

Conserved Domains (5) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

pfam11498
Location:343 → 533

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:650 → 968

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:662 → 710

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain
XM_030252936.2 → XP_030108796.1 WD repeat-containing protein 47 isoform X7

Conserved Domains (5) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

pfam11498
Location:343 → 533

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:650 → 966

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:662 → 710

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain
XM_030252935.1 → XP_030108795.1 WD repeat-containing protein 47 isoform X6

Conserved Domains (5) summary

smart00668
Location:95 → 152

CTLH; C-terminal to LisH motif

pfam11498
Location:343 → 532

Activator_LAG-3; Transcriptional activator LAG-3

cd00200
Location:649 → 967

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:661 → 709

7WD40; WD40 repeat [structural motif]

pfam17814
Location:63 → 90

LisH_TPL; LisH-like dimerisation domain