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    Grm3 glutamate receptor, metabotropic 3 [ Mus musculus (house mouse) ]

    Gene ID: 108069, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Grm3provided by MGI
    Official Full Name
    glutamate receptor, metabotropic 3provided by MGI
    Primary source
    MGI:MGI:1351340
    See related
    Ensembl:ENSMUSG00000003974 AllianceGenome:MGI:1351340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mGlu3; Gprc1c; mGluR3; 0710001G23Rik
    Summary
    Enables calcium channel regulator activity and group II metabotropic glutamate receptor activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within gene expression. Located in several cellular components, including axon; dendritic spine; and postsynaptic density. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Orthologous to human GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 11.5), frontal lobe adult (RPKM 9.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grm3 in Genome Data Viewer
    Location:
    5 A1; 5 3.69 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9535235..9776087, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (9485236..9725352, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene Neighboring gene STARR-seq mESC enhancer starr_12413 Neighboring gene STARR-seq mESC enhancer starr_12414 Neighboring gene microRNA 879 Neighboring gene STARR-seq mESC enhancer starr_12415 Neighboring gene STARR-seq mESC enhancer starr_12416 Neighboring gene STARR-seq mESC enhancer starr_12417 Neighboring gene predicted gene, 23312 Neighboring gene predicted gene, 35139

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. mGLU3 metabotropic glutamate receptors modulate the differentiation of SVZ-derived neural stem cells towards the astrocytic lineage. Ciceroni C, et al. Glia, 2010 May. PMID 20091783
    2. mGluR3 knockout mice show a working memory defect and an enhanced response to MK-801 in the T- and Y-maze cognitive tests. Lainiola M, et al. Behav Brain Res, 2014 Jun 1. PMID 24631392
    3. Metabotropic glutamate receptor 3 is downregulated and its expression is shifted from neurons to astrocytes in the mouse lateral septum during the postpartum period. Zhao C, et al. J Histochem Cytochem, 2015 Jun. PMID 25739438, Free PMC Article
    4. mGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia. Olszewski RT, et al. Schizophr Res, 2012 Apr. PMID 22300789
    5. Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells. Nakamichi N, et al. J Neurochem, 2008 Jun. PMID 18266930

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.
      Title: Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.
    2. Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits.
      Title: Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits.
    3. A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model.
      Title: A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model.
    4. Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
      Title: Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
    5. Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
      Title: Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
    6. mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
      Title: mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
    7. Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors.
      Title: Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu(3)) impairs postsynaptic plasticity and modulates affective behaviors.
    8. Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
      Title: Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
    9. mGlu3 receptor regulates microglial cell reactivity in neonatal rats.
      Title: mGlu3 receptor regulates microglial cell reactivity in neonatal rats.
    10. Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
      Title: Activating mGlu(3) Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables group II metabotropic glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables group II metabotropic glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables group II metabotropic glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of sensory perception of pain NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of pain TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic active zone NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metabotropic glutamate receptor 3
    Names
    G protein-coupled receptor, family C, group 1, member C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417964.1 → NP_001404893.1  metabotropic glutamate receptor 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC157555, AC162520
      UniProtKB/Swiss-Prot
      Q14DJ9, Q9QYS2

    2. NM_181850.3 → NP_862898.1  metabotropic glutamate receptor 3 precursor

      See identical proteins and their annotated locations for NP_862898.1

      Status: VALIDATED

      Source sequence(s)
      AC157555, AC162520
      Consensus CDS
      CCDS19090.1
      UniProtKB/Swiss-Prot
      Q14DJ9, Q9QYS2
      Related
      ENSMUSP00000004076.4, ENSMUST00000004076.5
      Conserved Domains (3) summary
      cd15448
      Location:575 → 828
      7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06375
      Location:33 → 494
      PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor
      pfam07562
      Location:505 → 555
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      9535235..9776087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164718.1 → XP_036020611.1  metabotropic glutamate receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      Q14DJ9, Q9QYS2
      Conserved Domains (3) summary
      cd15448
      Location:575 → 828
      7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06375
      Location:33 → 494
      PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor
      pfam07562
      Location:505 → 555
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    2. XM_036164719.1 → XP_036020612.1  metabotropic glutamate receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      Q14DJ9, Q9QYS2
      Conserved Domains (3) summary
      cd15448
      Location:575 → 828
      7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06375
      Location:33 → 494
      PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor
      pfam07562
      Location:505 → 555
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    3. XM_036164720.1 → XP_036020613.1  metabotropic glutamate receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      Q14DJ9, Q9QYS2
      Conserved Domains (3) summary
      cd15448
      Location:575 → 828
      7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06375
      Location:33 → 494
      PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor
      pfam07562
      Location:505 → 555
      NCD3G; Nine Cysteines Domain of family 3 GPCR
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYS2.1 GenPept UniProtKB/Swiss-Prot:Q9QYS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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