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    Creb5 cAMP responsive element binding protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 231991, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Creb5provided by MGI
    Official Full Name
    cAMP responsive element binding protein 5provided by MGI
    Primary source
    MGI:MGI:2443973
    See related
    Ensembl:ENSMUSG00000053007 AllianceGenome:MGI:2443973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crebpa; CRE-BPa; 9430076C15Rik; D430026C09Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in white fat cell differentiation. Acts upstream of or within adipose tissue development; fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including limb; neural tube; oral epithelium; palatal shelf; and telencephalon ventricular layer. Orthologous to human CREB5 (cAMP responsive element binding protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 2.1), subcutaneous fat pad adult (RPKM 1.0) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Creb5 in Genome Data Viewer
    Location:
    6 B3; 6 25.9 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (53264154..53677349)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (53287226..53700364)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15922 Neighboring gene predicted gene 4872 Neighboring gene predicted gene, 33348 Neighboring gene STARR-seq mESC enhancer starr_15923 Neighboring gene STARR-seq mESC enhancer starr_15924 Neighboring gene predicted gene, 25818 Neighboring gene predicted gene, 38815 Neighboring gene predicted gene, 38814 Neighboring gene STARR-seq mESC enhancer starr_15926 Neighboring gene predicted gene, 33392 Neighboring gene STARR-seq mESC enhancer starr_15930 Neighboring gene STARR-seq mESC enhancer starr_15931 Neighboring gene STARR-seq mESC enhancer starr_15932 Neighboring gene STARR-seq mESC enhancer starr_15933 Neighboring gene predicted gene, 57762 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations. Liu X, et al. Mucosal Immunol, 2022 Jun. PMID 36038770, Free PMC Article
    2. Dysregulation of CREB5 Impairs Decidualization and Maternal-Fetal Interactions by Inhibiting Autophagy in Recurrent Spontaneous Abortion. Li Z, et al. Reprod Sci, 2024 Jul. PMID 38424407
    3. The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. Maekawa T, et al. Mol Cell Biol, 2010 Feb. PMID 19948881, Free PMC Article
    4. Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage. Desanlis I, et al. J Dev Biol, 2020 Dec 7. PMID 33297480, Free PMC Article
    5. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication. Lehoczky JA, et al. Evol Dev, 2004 Nov-Dec. PMID 15509224

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysregulation of CREB5 Impairs Decidualization and Maternal-Fetal Interactions by Inhibiting Autophagy in Recurrent Spontaneous Abortion.
      Title: Dysregulation of CREB5 Impairs Decidualization and Maternal-Fetal Interactions by Inhibiting Autophagy in Recurrent Spontaneous Abortion.
    2. Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations.
      Title: Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations.
    3. TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.
      Title: TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in white fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in white fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic AMP-responsive element-binding protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327821.1 → NP_001314750.1  cyclic AMP-responsive element-binding protein 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC068064, AC068661, AC069141, AC079130, AK052451, BE943969
      Consensus CDS
      CCDS85049.1
      UniProtKB/TrEMBL
      A0A0N4SV71
      Related
      ENSMUSP00000144979.2, ENSMUST00000203528.3
      Conserved Domains (1) summary
      cd14687
      Location:370 → 429
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    2. NM_172728.2 → NP_766316.1  cyclic AMP-responsive element-binding protein 5 isoform 2

      See identical proteins and their annotated locations for NP_766316.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK052451
      Consensus CDS
      CCDS20153.1
      UniProtKB/Swiss-Prot
      Q3TCE1, Q3U228, Q8BWH8, Q8K1L0
      UniProtKB/TrEMBL
      A0A0N4SUK5
      Related
      ENSMUSP00000144719.2, ENSMUST00000205120.3
      Conserved Domains (1) summary
      cd14687
      Location:226 → 285
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      53264154..53677349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166039.1 → XP_036021932.1  cyclic AMP-responsive element-binding protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0N4SUW5
      Related
      ENSMUSP00000144851.2, ENSMUST00000203487.3
      Conserved Domains (1) summary
      cd14687
      Location:377 → 436
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    2. XM_036166040.1 → XP_036021933.1  cyclic AMP-responsive element-binding protein 5 isoform X2

      Conserved Domains (1) summary
      cd14687
      Location:377 → 436
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    3. XM_036166042.1 → XP_036021935.1  cyclic AMP-responsive element-binding protein 5 isoform X5

    4. XM_036166041.1 → XP_036021934.1  cyclic AMP-responsive element-binding protein 5 isoform X3

      UniProtKB/Swiss-Prot
      Q3TCE1, Q3U228, Q8BWH8, Q8K1L0
      Conserved Domains (1) summary
      cd14687
      Location:226 → 285
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    5. XM_011241296.3 → XP_011239598.1  cyclic AMP-responsive element-binding protein 5 isoform X4

      Conserved Domains (1) summary
      cd14687
      Location:148 → 207
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015553.2: Suppressed sequence

      Description
      NR_015553.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1L0.3 GenPept UniProtKB/Swiss-Prot:Q8K1L0

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