Sox6 SRY (sex determining region Y)-box 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sox6provided by MGI
Official Full Name: SRY (sex determining region Y)-box 6provided by MGI
Primary source: MGI:MGI:98368
See related: Ensembl:ENSMUSG00000051910 AllianceGenome:MGI:98368
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SOX-LZ
Summary: This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression: Ubiquitous expression in testis adult (RPKM 2.9), liver E14 (RPKM 2.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F1; 7 61.29 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (115070107..115639186, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (115470872..116040776, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-23b-3p alleviates Sjogren's syndrome by targeting SOX6 and inhibiting the NF-kappaB signaling.
Title: MiR-23b-3p alleviates Sjögren's syndrome by targeting SOX6 and inhibiting the NF-κB signaling.
Propranolol inhibits EMT and metastasis in breast cancer through miR-499-5p-mediated Sox6.
Title: Propranolol inhibits EMT and metastasis in breast cancer through miR-499-5p-mediated Sox6.
Sox6 impairs the adipogenic commitment of mesenchymal stem cells by targeting lysyl oxidase and preadipocyte factor 1.
Title: Sox6 impairs the adipogenic commitment of mesenchymal stem cells by targeting lysyl oxidase and preadipocyte factor 1.
KNOCKDOWN OF CIRC_0001379 ATTENUATES HYPOXIA/REOXYGENATION-INDUCED CARDIOMYOCYTE APOPTOSIS AND INFLAMMATORY RESPONSE BY MIR-98-5P/SOX6 AXIS.
Title: KNOCKDOWN OF CIRC_0001379 ATTENUATES HYPOXIA/REOXYGENATION-INDUCED CARDIOMYOCYTE APOPTOSIS AND INFLAMMATORY RESPONSE BY MIR-98-5P/SOX6 AXIS.
Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression.
Title: Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression.
The Transcription Factor Sox6 Controls Renin Expression during Renal Artery Stenosis.
Title: The Transcription Factor Sox6 Controls Renin Expression during Renal Artery Stenosis.
Suppression of MALAT1 alleviates neurocyte apoptosis and reactive oxygen species production through the miR-499-5p/SOX6 axis in subarachnoid hemorrhage.
Title: Suppression of MALAT1 alleviates neurocyte apoptosis and reactive oxygen species production through the miR-499-5p/SOX6 axis in subarachnoid hemorrhage.
LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2.
Title: LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2.
Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.
Title: Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.
Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons.
Title: Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa97a8.seq (e-PCR)
- UniSTS:125451

U32614 (e-PCR)
- UniSTS:125723

NoName (e-PCR)
- UniSTS:224818

D7Mit237 (e-PCR), detects polymorphism
- UniSTS:131130

D7Mit253 (e-PCR), detects polymorphism
- UniSTS:131149

D7Mit253.1 (e-PCR), detects polymorphism
- UniSTS:131150

RH125939 (e-PCR)
- UniSTS:162651

03.MHAa75a3.seq (e-PCR)
- UniSTS:122723

09.MMHAP57FRC9.seq (e-PCR)
- UniSTS:122982

Sox6 (e-PCR), detects polymorphism
- UniSTS:144490

UniSTS:144491 (e-PCR)
- UniSTS:144491

Sox6 (e-PCR), detects polymorphism
- UniSTS:144491

Sox6 (e-PCR), detects polymorphism
- UniSTS:536442

D7Dcr48 (e-PCR), detects polymorphism
- UniSTS:507807

AI987981 (e-PCR)
- UniSTS:165552

Sox6 (e-PCR), detects polymorphism
- UniSTS:516573

Sox6 (e-PCR), detects polymorphism
- UniSTS:536549

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cardiac muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cartilage condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spinal cord oligodendrocyte cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: transcription factor SOX-6

Names: SRY-box containing gene 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025559.3 → NP_001020730.1 transcription factor SOX-6 isoform 2

See identical proteins and their annotated locations for NP_001020730.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, and 7-9 all encode the same isoform (2).

Source sequence(s)

AC118676, AK030713, AK048143, AW047933

UniProtKB/TrEMBL

E9PUW0, Q6NWW0

Related

ENSMUSP00000129512.2, ENSMUST00000166877.8

Conserved Domains (1) summary

cd01388
Location:579 → 650

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_001025560.3 → NP_001020731.1 transcription factor SOX-6 isoform 3

See identical proteins and their annotated locations for NP_001020731.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579

Consensus CDS

CCDS40097.1

UniProtKB/TrEMBL

Q6NWW0, Q8BSS6

Related

ENSMUSP00000102223.2, ENSMUST00000106612.8

Conserved Domains (1) summary

cd01388
Location:577 → 648

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_001277326.2 → NP_001264255.1 transcription factor SOX-6 isoform 1

See identical proteins and their annotated locations for NP_001264255.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Both variants 1 and 4 encode the same isoform (1).

Source sequence(s)

AC107371, AC111041, AC118676, AC158579

Consensus CDS

CCDS40098.1

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Related

ENSMUSP00000129027.2, ENSMUST00000166207.3

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_001277327.2 → NP_001264256.1 transcription factor SOX-6 isoform 2

See identical proteins and their annotated locations for NP_001264256.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, and 7-9 all encode the same isoform (2).

Source sequence(s)

AC107371, AC111041, AC118676, AC158579

Consensus CDS

CCDS52369.1

UniProtKB/TrEMBL

E9PUW0, Q6NWW0

Related

ENSMUSP00000126404.2, ENSMUST00000169129.8

Conserved Domains (1) summary

cd01388
Location:579 → 650

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_001277328.2 → NP_001264257.1 transcription factor SOX-6 isoform 4

See identical proteins and their annotated locations for NP_001264257.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Variants 6 and 10-12 all encode the same isoform (4).

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:578 → 649

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
NM_001417295.1 → NP_001404224.1 transcription factor SOX-6 isoform 2

Status: REVIEWED

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579

UniProtKB/TrEMBL

E9PUW0
NM_001417296.1 → NP_001404225.1 transcription factor SOX-6 isoform 2

Status: REVIEWED

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579

UniProtKB/TrEMBL

E9PUW0
NM_001417297.1 → NP_001404226.1 transcription factor SOX-6 isoform 2

Status: REVIEWED

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579

UniProtKB/TrEMBL

E9PUW0
NM_001417298.1 → NP_001404227.1 transcription factor SOX-6 isoform 4

Status: REVIEWED

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579
NM_001417299.1 → NP_001404228.1 transcription factor SOX-6 isoform 4

Status: REVIEWED

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579
NM_001417300.1 → NP_001404229.1 transcription factor SOX-6 isoform 4

Status: REVIEWED

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579
NM_001417301.1 → NP_001404230.1 transcription factor SOX-6 isoform 5

Status: REVIEWED

Source sequence(s)

AC107371, AC118676
NM_001417302.1 → NP_001404231.1 transcription factor SOX-6 isoform 6

Status: REVIEWED

Source sequence(s)

AC107371, AC118676
NM_001417303.1 → NP_001404232.1 transcription factor SOX-6 isoform 7

Status: REVIEWED

Source sequence(s)

AC107371
NM_011445.5 → NP_035575.1 transcription factor SOX-6 isoform 1

See identical proteins and their annotated locations for NP_035575.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 4 encode the same isoform (1).

Source sequence(s)

AC102696, AC107371, AC111041, AC118676, AC158579

Consensus CDS

CCDS40098.1

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Related

ENSMUSP00000072583.5, ENSMUST00000072804.11

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

115070107..115639186 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242296.2 → XP_030098156.1 transcription factor SOX-6 isoform X7

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:578 → 649

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242290.2 → XP_030098150.1 transcription factor SOX-6 isoform X6

UniProtKB/TrEMBL

E9PUW0, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:579 → 650

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152834.1 → XP_036008727.1 transcription factor SOX-6 isoform X3

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242303.1 → XP_030098163.1 transcription factor SOX-6 isoform X11

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:558 → 629

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152838.1 → XP_036008731.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:599 → 670

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242289.2 → XP_030098149.1 transcription factor SOX-6 isoform X4

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:600 → 671

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242297.2 → XP_030098157.1 transcription factor SOX-6 isoform X7

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:578 → 649

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242285.2 → XP_030098145.1 transcription factor SOX-6 isoform X3

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152847.1 → XP_036008740.1 transcription factor SOX-6 isoform X11

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:558 → 629

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152848.1 → XP_036008741.1 transcription factor SOX-6 isoform X11

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:558 → 629

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242286.2 → XP_030098146.1 transcription factor SOX-6 isoform X3

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152837.1 → XP_036008730.1 transcription factor SOX-6 isoform X3

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152836.1 → XP_036008729.1 transcription factor SOX-6 isoform X3

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011241707.4 → XP_011240009.1 transcription factor SOX-6 isoform X3

See identical proteins and their annotated locations for XP_011240009.1

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242300.2 → XP_030098160.1 transcription factor SOX-6 isoform X7

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:578 → 649

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152833.1 → XP_036008726.1 transcription factor SOX-6 isoform X1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242274.2 → XP_030098134.1 transcription factor SOX-6 isoform X1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152843.1 → XP_036008736.1 transcription factor SOX-6 isoform X9

UniProtKB/TrEMBL

Q6NWW0, Q8BSS6

Conserved Domains (1) summary

cd01388
Location:577 → 648

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152842.1 → XP_036008735.1 transcription factor SOX-6 isoform X8

UniProtKB/TrEMBL

A0A0U1RPC1, Q6NWW0

Related

ENSMUSP00000145919.2, ENSMUST00000206034.2

Conserved Domains (1) summary

cd01388
Location:578 → 649

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242275.2 → XP_030098135.1 transcription factor SOX-6 isoform X1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242284.2 → XP_030098144.1 transcription factor SOX-6 isoform X2

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_017322070.3 → XP_017177559.1 transcription factor SOX-6 isoform X1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242291.2 → XP_030098151.1 transcription factor SOX-6 isoform X6

UniProtKB/TrEMBL

E9PUW0, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:579 → 650

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006507498.5 → XP_006507561.1 transcription factor SOX-6 isoform X1

See identical proteins and their annotated locations for XP_006507561.1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242278.2 → XP_030098138.1 transcription factor SOX-6 isoform X1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Related

ENSMUSP00000145732.2, ENSMUST00000205405.2

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006507499.5 → XP_006507562.1 transcription factor SOX-6 isoform X1

See identical proteins and their annotated locations for XP_006507562.1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006507497.5 → XP_006507560.1 transcription factor SOX-6 isoform X1

See identical proteins and their annotated locations for XP_006507560.1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242277.2 → XP_030098137.1 transcription factor SOX-6 isoform X1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152831.1 → XP_036008724.1 transcription factor SOX-6 isoform X1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006507501.5 → XP_006507564.1 transcription factor SOX-6 isoform X1

See identical proteins and their annotated locations for XP_006507564.1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242287.2 → XP_030098147.1 transcription factor SOX-6 isoform X2

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152835.1 → XP_036008728.1 transcription factor SOX-6 isoform X3

UniProtKB/Swiss-Prot

P40645, Q62250, Q9QWS5

UniProtKB/TrEMBL

Q3V1J7, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:619 → 690

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152832.1 → XP_036008725.1 transcription factor SOX-6 isoform X1

UniProtKB/TrEMBL

A0A0U1RNW8, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_030242302.2 → XP_030098162.1 transcription factor SOX-6 isoform X8

UniProtKB/TrEMBL

A0A0U1RPC1, Q6NWW0

Conserved Domains (1) summary

cd01388
Location:578 → 649

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_011241715.4 → XP_011240017.1 transcription factor SOX-6 isoform X12

Conserved Domains (1) summary

cd01388
Location:427 → 498

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006507514.5 → XP_006507577.1 transcription factor SOX-6 isoform X13

Conserved Domains (1) summary

cd01388
Location:356 → 427

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152844.1 → XP_036008737.1 transcription factor SOX-6 isoform X10

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:559 → 630

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152846.1 → XP_036008739.1 transcription factor SOX-6 isoform X10

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:559 → 630

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152845.1 → XP_036008738.1 transcription factor SOX-6 isoform X10

UniProtKB/TrEMBL

Q6NWW0

Conserved Domains (1) summary

cd01388
Location:559 → 630

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_036152849.1 → XP_036008742.1 transcription factor SOX-6 isoform X14