Tmem123 transmembrane protein 123 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem123provided by MGI
Official Full Name: transmembrane protein 123provided by MGI
Primary source: MGI:MGI:1919179
See related: Ensembl:ENSMUSG00000050912 AllianceGenome:MGI:1919179
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310075C12Rik
Summary: Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasmic vesicle. Orthologous to human TMEM123 (transmembrane protein 123). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 117.5), mammary gland adult (RPKM 52.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (7764078..7794334)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (7764077..7794333)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tmem123 may be used as a new maturation marker in DCs and that this molecule may be closely associated with the cell surface expression of CD40.
Title: Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: porimin

Names: pro-oncosis receptor inducing membrane injury

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133739.2 → NP_598500.1 porimin precursor

See identical proteins and their annotated locations for NP_598500.1

Status: VALIDATED

Source sequence(s)

AI448519, AK150361, AK162610, BY259389

Consensus CDS

CCDS22810.1

UniProtKB/Swiss-Prot

Q3T9F6, Q3TLL2, Q3U1R6, Q8CEX4, Q91Z22

Related

ENSMUSP00000051966.10, ENSMUST00000052865.16

Conserved Domains (2) summary

PRK13335
Location:44 → 144

PRK13335; superantigen-like protein SSL3; Reviewed

pfam05283
Location:95 → 175

MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

RNA

NR_152989.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AI448519, CT030639

Related

ENSMUST00000154371.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

7764078..7794334

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155305.1 → XP_036011198.1 porimin isoform X1

Conserved Domains (2) summary

PRK11907
Location:11 → 107

PRK11907; bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase

pfam05283
Location:61 → 132

MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin