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    bgs1 primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540737, updated on 18-Sep-2024

    Summary

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    Official Symbol
    bgs1
    Official Full Name
    primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1
    Primary source
    PomBase:SPBC19G7.05c
    Locus tag
    SPOM_SPBC19G7.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cps1; drc1; swl1
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    Genomic context

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    See bgs1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2350922..2357364, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein-DNA covalent cross-linking repair protein Neighboring gene 4-amino-4-deoxychorismate lyase Neighboring gene 40S ribosomal protein eS30 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-binding transcription factor, MADS-box Mbx1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two S. pombe septation phases differ in ingression rate, septum structure, and response to F-actin loss. Ramos M, et al. J Cell Biol, 2019 Dec 2. PMID 31597680, Free PMC Article
    2. cps1+, a Schizosaccharomyces pombe gene homolog of Saccharomyces cerevisiae FKS genes whose mutation confers hypersensitivity to cyclosporin A and papulacandin B. Ishiguro J, et al. J Bacteriol, 1997 Dec. PMID 9401022, Free PMC Article
    3. Localization of the (1,3)beta-D-glucan synthase catalytic subunit homologue Bgs1p/Cps1p from fission yeast suggests that it is involved in septation, polarized growth, mating, spore wall formation and spore germination. Cortés JC, et al. J Cell Sci, 2002 Nov 1. PMID 12356913
    4. Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe. Liu J, et al. Genetics, 1999 Nov. PMID 10545452, Free PMC Article
    5. Sbg1 Is a Novel Regulator for the Localization of the β-Glucan Synthase Bgs1 in Fission Yeast. Davidson R, et al. PLoS One, 2016. PMID 27898700, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bgs1 has a role in both the first septation phase where it is lost from the immature septum after F-actin removal, and in the second phase where the septum septum can maintain a Bgs1 ring and septum ingression without F-actin, but ingression becomes Cdc42 and exocyst dependent
      Title: Two S. pombe septation phases differ in ingression rate, septum structure, and response to F-actin loss.
    2. Findings suggest that septins act as key players in an accurate establishment and the maintenance of contractile actomyosin ring (CAR) by orchestrating the equatorial dynamics of separation initiation network kinase Sid2p (Sid2p) and glucan synthases Bgs1p and Ags1p.
      Title: Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis.
    3. Sbg1 and Bgs1 physically interact and are interdependent for localization to the plasma membrane
      Title: Sbg1 Is a Novel Regulator for the Localization of the β-Glucan Synthase Bgs1 in Fission Yeast.
    4. Sbg1p and Bgs1p physically interact and are dependent on each other to localize to the division site. Loss of Sbg1p results in an unstable actomyosin ring that unravels and slides, leading to an inability to deposit a single contiguous division septum and an important reduction of the beta-1,3-glucan proportion in the cell wal
      Title: A New Membrane Protein Sbg1 Links the Contractile Ring Apparatus and Septum Synthesis Machinery in Fission Yeast.
    5. Findings reveal a role for Sip1 in the regulation of Golgi/endosome trafficking in coordination with the AP-1 complex, and identified Bgs1, required for cell wall synthesis, as the new cargo of AP-1-dependent trafficking.
      Title: Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast.
    6. cytokinesis machinery integrity under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p
      Title: The integrity of the cytokinesis machinery under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p.
    7. fission yeast SEL1 domain protein Cfh3p is a novel regulator of the glucan synthase Bgs1p whose function is more relevant under stress conditions
      Title: The fission yeast SEL1 domain protein Cfh3p: a novel regulator of the glucan synthase Bgs1p whose function is more relevant under stress conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 1,3-beta-D-glucan synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,3-beta-D-glucan synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in (1->3)-beta-D-glucan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall polysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary cell septum biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 1,3-beta-D-glucan synthase complex IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in old growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2350922..2357364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021879.3 → NP_595971.1  primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595971.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10287
      Conserved Domains (2) summary
      pfam02364
      Location:693 → 1508
      Glucan_synthase; 1,3-beta-glucan synthase component
      pfam14288
      Location:186 → 292
      FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
    Nucleotide Protein
    Heading Accession and Version

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