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    tbf1 DNA-binding factor Trf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540732, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tbf1
    Official Full Name
    DNA-binding factor Trf1
    Primary source
    PomBase:SPBC19G7.13
    Locus tag
    SPOM_SPBC19G7.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    trf1
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    Genomic context

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    See tbf1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2373925..2376516)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene COG complex subunit Cog5 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor. Wu Z, et al. Structure, 2024 Jul 11. PMID 38677290
    2. Identification and characterization of an essential telomeric repeat binding factor in fission yeast. Pitt CW, et al. J Biol Chem, 2008 Feb 1. PMID 17977837
    3. Functional differentiation of tbf1 orthologues in fission and budding yeasts. Cockell MM, et al. Eukaryot Cell, 2009 Feb. PMID 19074598, Free PMC Article
    4. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor.
      Title: Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor.
    2. Fission and budding yeast Tbf1 proteins have diverged significantly in their functions.
      Title: Functional differentiation of tbf1 orthologues in fission and budding yeasts.
    3. Targeted deletion of the tbf1 gene reveals that it is essential for survival, and overexpression of the tbf1 gene leads to telomere elongation in vivo, which is dependent upon the MYB domain.
      Title: Identification and characterization of an essential telomeric repeat binding factor in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables double-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via telomere lengthening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding factor Trf1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2373925..2376516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021886.3 → NP_595979.1  DNA-binding factor Trf1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595979.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42961, Q6E434, Q9US79
      Conserved Domains (3) summary
      smart00717
      Location:405 → 461
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11660
      Location:406 → 461
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      pfam08558
      Location:98 → 319
      TRF; Telomere repeat binding factor (TRF)
    Nucleotide Protein
    Heading Accession and Version

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