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    cka1 serine/threonine protein kinase Cka1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541972, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cka1
    Official Full Name
    serine/threonine protein kinase Cka1
    Primary source
    PomBase:SPAC23C11.11
    Locus tag
    SPOM_SPAC23C11.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    orb5
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    Genomic context

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    See cka1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (2152037..2154223)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene alanine--tRNA (Ala) ligase Ala1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 3'-5'-RNA exonuclease Mpn1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene anaphase-promoting complex TPR lobe accessory factor subunit Hcn1/Apc12 Neighboring gene xanthine phosphoribosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth. Snell V, et al. EMBO J, 1994 May 1. PMID 8187760, Free PMC Article
    2. Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast. Nakazawa N, et al. J Biol Chem, 2019 Mar 8. PMID 30635402, Free PMC Article
    3. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Shimada M, et al. Biochem Biophys Res Commun, 2009 Oct 23. PMID 19666000
    4. The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit. Roussou I, et al. Mol Cell Biol, 1994 Jan. PMID 8264625, Free PMC Article
    5. N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity. Nishibuchi G, et al. Nucleic Acids Res, 2014 Nov 10. PMID 25332400, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Substitution of a conserved methionine residue to phenylalanine in Plo1, Orb5 and Wee1 kinases increased the sensitivities to ATP analogues.
      Title: Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.
    2. These results suggest that CK2 has a role in the spindle checkpoint by regulating Mad2p.
      Title: Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment or maintenance of bipolar cell polarity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in signaling NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    part_of UTP-C complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus HDA PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase CK2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase Cka1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2152037..2154223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019073.3 → NP_593642.1  serine/threonine protein kinase Cka1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593642.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40231
      Conserved Domains (2) summary
      smart00220
      Location:43 → 328
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14132
      Location:24 → 329
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    Nucleotide Protein
    Heading Accession and Version

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