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    pyp1 protein tyrosine phosphatase Pyp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542677, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pyp1
    Official Full Name
    protein tyrosine phosphatase Pyp1
    Primary source
    PomBase:SPAC26F1.10c
    Locus tag
    SPOM_SPAC26F1.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pyp1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5161512..5163360)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase-activating protein Gyp51 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 2C acts independently of stress-activated kinase cascade to regulate the stress response in fission yeast. Gaits F, et al. J Biol Chem, 1997 Jul 11. PMID 9211944
    2. Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast. Gaits F, et al. Mol Biol Cell, 1999 May. PMID 10233152, Free PMC Article
    3. Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast. Humphrey T, et al. Genetics, 1998 Apr. PMID 9560390, Free PMC Article
    4. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. Millar JB, et al. EMBO J, 1992 Dec. PMID 1464319, Free PMC Article
    5. Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe. Shimasaki T, et al. Mol Genet Genomics, 2014 Aug. PMID 24696293

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables MAP kinase tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of p38MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of p38MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in protein aggregate center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein tyrosine phosphatase Pyp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5161512..5163360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020314.3 → NP_594885.1  protein tyrosine phosphatase Pyp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594885.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P27574
      Conserved Domains (3) summary
      COG5599
      Location:244 → 548
      COG5599; Protein tyrosine phosphatase [Signal transduction mechanisms]
      cd00047
      Location:297 → 536
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cl00125
      Location:41 → 161
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    Nucleotide Protein
    Heading Accession and Version

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