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    PRKDC protein kinase, DNA-activated, catalytic subunit [ Trichosurus vulpecula (common brushtail) ]

    Gene ID: 118830241, updated on 20-Mar-2024

    Summary

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    Gene symbol
    PRKDC
    Gene description
    protein kinase, DNA-activated, catalytic subunit
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Trichosurus vulpecula
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Diprotodontia; Phalangeridae; Trichosurus
    Orthologs
    human mouse all
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    Genomic context

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    See PRKDC in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    86
    Annotation release Status Assembly Chr Location
    100 current mTriVul1.pri (GCF_011100635.1) 1 NC_050573.1 (259755265..259922559, complement)

    Chromosome 1 - NC_050573.1Genomic Context describing neighboring genes Neighboring gene scaffold protein involved in DNA repair Neighboring gene 60S ribosomal protein L30-like Neighboring gene CCAAT enhancer binding protein delta Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene minichromosome maintenance complex component 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_050573.1 Chromosome 1 Reference mTriVul1.pri Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-dependent protein kinase catalytic subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Trichosurus vulpecula Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mTriVul1.pri Primary Assembly

    Genomic

    1. NC_050573.1 Reference mTriVul1.pri Primary Assembly

      Range
      259755265..259922559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036737168.1 → XP_036593063.1  DNA-dependent protein kinase catalytic subunit

      Conserved Domains (5) summary
      COG5032
      Location:3507 → 4023
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05172
      Location:3727 → 4023
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:3033 → 3478
      FAT; FAT domain
      pfam02260
      Location:4105 → 4136
      FATC; FATC domain
      pfam08163
      Location:1823 → 2209
      NUC194; NUC194 domain
    Nucleotide Protein
    Heading Accession and Version

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