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    MBTPS2 membrane bound transcription factor peptidase, site 2 [ Talpa occidentalis (Iberian mole) ]

    Gene ID: 119246281, updated on 21-Mar-2024

    Summary

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    Gene symbol
    MBTPS2
    Gene description
    membrane bound transcription factor peptidase, site 2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Talpa occidentalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Talpidae; Talpa
    Orthologs
    human mouse all
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    Genomic context

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    See MBTPS2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_03 current MPIMG_talOcc4v2.1 (GCF_014898055.3) Unplaced Scaffold NW_023601543.1 (77707997..77750254, complement)

    NW_023601543.1Genomic Context describing neighboring genes Neighboring gene phosphate regulating endopeptidase X-linked Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene spermine synthase Neighboring gene uncharacterized LOC119246777 Neighboring gene YY2 transcription factor Neighboring gene small muscle protein X-linked

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_023601543 Unplaced Scaffold Reference MPIMG_talOcc4v2.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane protein intracellular domain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane-bound transcription factor site-2 protease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_014898055.3-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference MPIMG_talOcc4v2.1 Primary Assembly

    Genomic

    1. NW_023601543.1 Reference MPIMG_talOcc4v2.1 Primary Assembly

      Range
      77707997..77750254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_037512615.2 → XP_037368512.1  membrane-bound transcription factor site-2 protease isoform X1

      Conserved Domains (2) summary
      cd06162
      Location:14 → 244
      S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
      pfam02163
      Location:161 → 502
      Peptidase_M50; Peptidase family M50

    2. XM_054695814.1 → XP_054551789.1  membrane-bound transcription factor site-2 protease isoform X2

    Nucleotide Protein
    Heading Accession and Version

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