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    gba-2 Putative glucosylceramidase 2 [ Caenorhabditis elegans ]

    Gene ID: 183155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gba-2
    Official Full Name
    Putative glucosylceramidase 2
    Primary source
    WormBase:WBGene00016340
    Locus tag
    CELE_C33C12.8
    See related
    AllianceGenome:WB:WBGene00016340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gba-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (2182494..2186434, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene AMP-binding_C domain-containing protein Neighboring gene Putative glucosylceramidase 1 Neighboring gene Methyltransferase small domain-containing protein Neighboring gene Membralin;TMV resistance protein N-like Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
    2. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glucosylceramidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosylceramidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucosylceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative glucosylceramidase 2
    NP_494208.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2182494..2186434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061807.7 → NP_494208.2  Putative glucosylceramidase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494208.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16581
      Conserved Domains (2) summary
      pfam02055
      Location:98 → 443
      Glyco_hydro_30; Glycosyl hydrolase family 30 TIM-barrel domain
      pfam17189
      Location:446 → 512
      Glyco_hydro_30C; Glycosyl hydrolase family 30 beta sandwich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16581.2

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