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    obr-1 Oxysterol-binding protein [ Caenorhabditis elegans ]

    Gene ID: 176555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    obr-1
    Official Full Name
    Oxysterol-binding protein
    Primary source
    WormBase:WBGene00012930
    Locus tag
    CELE_Y47D3A.17
    See related
    AllianceGenome:WB:WBGene00012930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sterol binding activity. Predicted to be involved in lipid transport. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See obr-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    17
    Sequence:
    Chromosome: III; NC_003281.10 (11257300..11270895, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S6 kinase beta Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multivesicular body formation requires OSBP-related proteins and cholesterol. Kobuna H, et al. PLoS Genet, 2010 Aug 5. PMID 20700434, Free PMC Article
    2. Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Park WS, et al. Mol Cell, 2008 May 9. PMID 18471983, Free PMC Article
    3. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Oxysterol-binding protein
    NP_001122730.1
    • Confirmed by transcript evidence
    NP_001367172.1
    • Confirmed by transcript evidence
    NP_001367300.1
    • Confirmed by transcript evidence
    NP_001379284.1
    • Confirmed by transcript evidence
    NP_499448.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11257300..11270895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067047.6 → NP_499448.1  Oxysterol-binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2C7
      Conserved Domains (3) summary
      pfam00169
      Location:61 → 150
      PH; PH domain
      pfam01237
      Location:382 → 746
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:63 → 162
      PH-like; Pleckstrin homology-like domain

    2. NM_001129258.5 → NP_001122730.1  Oxysterol-binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7DTF3
      Conserved Domains (1) summary
      pfam01237
      Location:65 → 429
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_001392212.1 → NP_001379284.1  Oxysterol-binding protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Q23
      Conserved Domains (2) summary
      COG4372
      Location:4 → 178
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam01237
      Location:243 → 613
      Oxysterol_BP; Oxysterol-binding protein

    4. NM_001379928.1 → NP_001367300.1  Oxysterol-binding protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2HK04
      Conserved Domains (3) summary
      COG4372
      Location:92 → 283
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam01237
      Location:348 → 718
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:29 → 128
      PH-like; Pleckstrin homology-like domain

    5. NM_001379929.1 → NP_001367172.1  Oxysterol-binding protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7DTF2
      Conserved Domains (3) summary
      COG4372
      Location:202 → 393
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam01237
      Location:458 → 828
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:170 → 238
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
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