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    Pex2 peroxisomal biogenesis factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29534, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pex2provided by RGD
    Official Full Name
    peroxisomal biogenesis factor 2provided by RGD
    Primary source
    RGD:61814
    See related
    EnsemblRapid:ENSRNOG00000008748 AllianceGenome:RGD:61814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pxmp3
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cell population proliferation; and pexophagy. Predicted to act upstream of or within several processes, including bile acid biosynthetic process; cholesterol homeostasis; and regulation of cholesterol biosynthetic process. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 5B and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 124.2), Muscle (RPKM 95.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pex2 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (97957479..97973767)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (96050380..96072928)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (98251756..98269185)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 1 pseudogene Neighboring gene phosphoglycerate kinase 1, pseudogene 3 Neighboring gene zinc finger homeobox 4 Neighboring gene inosine monophosphate dehydrogenase 1, pseudogene 1 Neighboring gene uncharacterized LOC134485886

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cellular response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pexophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pexophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pexophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into peroxisome matrix ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into peroxisome matrix, receptor recycling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into peroxisome matrix, receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into peroxisome matrix, receptor recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amino acid starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in very long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cdc73/Paf1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisome biogenesis factor 2
    Names
    PAF-1
    peroxin-2
    peroxisomal membrane protein 3, 35 kDa
    peroxisome assembly factor 1
    NP_001375433.1
    NP_001375434.1
    NP_001375435.1
    NP_058930.2
    XP_006232221.1
    XP_008759087.1
    XP_063137709.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388504.1NP_001375433.1  peroxisome biogenesis factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      FM104606, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P24392, Q63733
      UniProtKB/TrEMBL
      A0A8L2Q557, A6IH90
      Conserved Domains (2) summary
      cd16526
      Location:243284
      RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
      pfam04757
      Location:27224
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    2. NM_001388505.1NP_001375434.1  peroxisome biogenesis factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P24392, Q63733
      UniProtKB/TrEMBL
      A0A8L2Q557, A6IH90
      Related
      ENSRNOP00000076831.1, ENSRNOT00000095560.2
      Conserved Domains (2) summary
      cd16526
      Location:243284
      RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
      pfam04757
      Location:27224
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    3. NM_001388506.1NP_001375435.1  peroxisome biogenesis factor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8L2Q557
      Conserved Domains (2) summary
      cd16526
      Location:280321
      RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
      pfam04757
      Location:64261
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    4. NM_017234.2NP_058930.2  peroxisome biogenesis factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      FM078955, FM104606, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P24392, Q63733
      UniProtKB/TrEMBL
      A0A8L2Q557, A6IH90
      Related
      ENSRNOP00000108095.1, ENSRNOT00000151330.1
      Conserved Domains (2) summary
      cd16526
      Location:243284
      RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
      pfam04757
      Location:27224
      Pex2_Pex12; Pex2 / Pex12 amino terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      97957479..97973767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232159.4XP_006232221.1  peroxisome biogenesis factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006232221.1

      UniProtKB/TrEMBL
      A0A8L2Q557
      Conserved Domains (2) summary
      cd16526
      Location:280321
      RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
      pfam04757
      Location:64261
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    2. XM_008760865.4XP_008759087.1  peroxisome biogenesis factor 2 isoform X1

      See identical proteins and their annotated locations for XP_008759087.1

      UniProtKB/TrEMBL
      A0A8L2Q557
      Conserved Domains (2) summary
      cd16526
      Location:280321
      RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
      pfam04757
      Location:64261
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    3. XM_063281639.1XP_063137709.1  peroxisome biogenesis factor 2 isoform X2

      UniProtKB/Swiss-Prot
      P24392, Q63733
      UniProtKB/TrEMBL
      A0A8L2Q557, A6IH90