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    SPDYE3 speedy/RINGO cell cycle regulator family member E3 [ Homo sapiens (human) ]

    Gene ID: 441272, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPDYE3provided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E3provided by HGNC
    Primary source
    HGNC:HGNC:35462
    See related
    Ensembl:ENSG00000214300 MIM:617625; AllianceGenome:HGNC:35462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPDYB2
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 3.8), lymph node (RPKM 1.4) and 23 other tissues See more
    Orthologs
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    Genomic context

    See SPDYE3 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100307702..100322196)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101547789..101562282)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99905325..99919819)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene STAG3 cohesin complex component Neighboring gene CASTOR family member 3, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26352 Neighboring gene PVR related immunoglobulin domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99844389-99845186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99845985-99846781 Neighboring gene uncharacterized LOC105375426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99866902-99867424 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99867949-99868470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18429 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99886514-99886677 Neighboring gene STAG3L5P-PVRIG2P-PILRB readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99932790-99933668 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26355 Neighboring gene STAG3 cohesin complex component like 5, pseudogene Neighboring gene PVR related immunoglobulin domain containing 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    speedy protein E3
    Names
    Putative WBSCR19-like protein 7
    putative Speedy protein E3
    speedy homolog E3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004351.5NP_001004351.3  speedy protein E3

      See identical proteins and their annotated locations for NP_001004351.3

      Status: VALIDATED

      Source sequence(s)
      BC056606, BC100972
      Consensus CDS
      CCDS47658.2
      UniProtKB/Swiss-Prot
      A6NKU9, Q495Y9, Q6PHC4
      Related
      ENSP00000329565.6, ENST00000332397.6
      Conserved Domains (1) summary
      pfam11357
      Location:391545
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100307702..100322196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420404.1XP_047276360.1  speedy protein E3 isoform X1

      UniProtKB/Swiss-Prot
      A6NKU9, Q495Y9, Q6PHC4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101547789..101562282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358260.1XP_054214235.1  speedy protein E3 isoform X1

      UniProtKB/Swiss-Prot
      A6NKU9, Q495Y9, Q6PHC4