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    Fpgt fucose-1-phosphate guanylyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310935, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fpgtprovided by RGD
    Official Full Name
    fucose-1-phosphate guanylyltransferaseprovided by RGD
    Primary source
    RGD:735121
    See related
    EnsemblRapid:ENSRNOG00000009548 AllianceGenome:RGD:735121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fucose-1-phosphate guanylyltransferase activity. Predicted to be involved in L-fucose metabolic process. Orthologous to human FPGT (fucose-1-phosphate guanylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 64.8), Liver (RPKM 44.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fpgt in Genome Data Viewer
    Location:
    2q45
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (246757982..246778896, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (244099031..244119967, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (261382015..261402950, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, pseudogene 3 Neighboring gene TNNI3 interacting kinase Neighboring gene leucine rich repeat containing 53 Neighboring gene leucine-rich repeats and IQ motif containing 3 Neighboring gene uncharacterized LOC134486009 Neighboring gene ribosomal protein L32, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme. Pastuszak I, et al. J Biol Chem, 1998 Nov 13. PMID 9804772
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fucose-1-phosphate guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-L-fucose salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-fucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fucose-1-phosphate guanylyltransferase
    Names
    gdp-L-fucose pyrophosphorylase
    NP_001376152.1
    NP_955788.2
    XP_038958413.1
    XP_038958416.1
    XP_063138050.1
    XP_063138051.1
    XP_063138052.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389223.1 → NP_001376152.1  fucose-1-phosphate guanylyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      Q5I0Q1
      Related
      ENSRNOP00000074607.1, ENSRNOT00000077839.3
      Conserved Domains (1) summary
      PRK13412
      Location:63 → 107
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional

    2. NM_199494.2 → NP_955788.2  fucose-1-phosphate guanylyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K0C0, A6HWQ9, B4F7E4
      Related
      ENSRNOP00000071383.1, ENSRNOT00000088561.3
      Conserved Domains (1) summary
      pfam07959
      Location:106 → 524
      Fucokinase; L-fucokinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      246757982..246778896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281982.1 → XP_063138052.1  fucose-1-phosphate guanylyltransferase isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZJ53

    2. XM_063281981.1 → XP_063138051.1  fucose-1-phosphate guanylyltransferase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZPW3

    3. XM_039102488.2 → XP_038958416.1  fucose-1-phosphate guanylyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZJ53
      Conserved Domains (1) summary
      PRK13412
      Location:63 → 113
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional

    4. XM_039102485.2 → XP_038958413.1  fucose-1-phosphate guanylyltransferase isoform X1

      Conserved Domains (1) summary
      pfam07959
      Location:1 → 390
      Fucokinase; L-fucokinase

    5. XM_063281980.1 → XP_063138050.1  fucose-1-phosphate guanylyltransferase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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