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    KMT2A lysine methyltransferase 2A [ Chlorocebus sabaeus (green monkey) ]

    Gene ID: 103248594, updated on 11-Mar-2024

    Summary

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    Gene symbol
    KMT2A
    Gene description
    lysine methyltransferase 2A
    See related
    Ensembl:ENSCSAG00000002585
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Chlorocebus sabaeus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus
    Orthologs
    human mouse all
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    Genomic context

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    See KMT2A in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    102 current Vero_WHO_p1.0 (GCF_015252025.1) Unplaced Scaffold NW_023666043.1 (16125381..16218277, complement)
    100 previous assembly Chlorocebus_sabeus 1.1 (GCF_000409795.2) 1 NC_023642.1 (109819748..109912763)

    NW_023666043.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene ATP synthase membrane subunit g Neighboring gene ubiquitination factor E4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Chlorocebus sabaeus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Vero_WHO_p1.0

    Genomic

    1. NW_023666043.1 Reference Vero_WHO_p1.0

      Range
      16125381..16218277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038005128.1 → XP_037861056.1  histone-lysine N-methyltransferase 2A isoform X2

      UniProtKB/TrEMBL
      A0A0D9S3M1
      Conserved Domains (9) summary
      cd05493
      Location:1681 → 1811
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3703 → 3786
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1465 → 1511
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1513 → 1561
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1599 → 1658
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1905 → 2017
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1179 → 1226
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3850 → 4003
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2058 → 2105
      FYRN; F/Y-rich N-terminus

    2. XM_008021067.2 → XP_008019258.2  histone-lysine N-methyltransferase 2A isoform X5

      UniProtKB/TrEMBL
      A0A0D9S3M1
      Conserved Domains (9) summary
      cd05493
      Location:1646 → 1776
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3668 → 3751
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1432 → 1478
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1480 → 1529
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1567 → 1623
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1870 → 1982
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1146 → 1193
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3815 → 3968
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2023 → 2070
      FYRN; F/Y-rich N-terminus

    3. XM_008021066.2 → XP_008019257.2  histone-lysine N-methyltransferase 2A isoform X4

      UniProtKB/TrEMBL
      A0A0D9S3M1
      Conserved Domains (9) summary
      cd05493
      Location:1649 → 1779
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3671 → 3754
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1432 → 1478
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1480 → 1529
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1567 → 1626
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1873 → 1985
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1146 → 1193
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3818 → 3971
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2026 → 2073
      FYRN; F/Y-rich N-terminus

    4. XM_038005129.1 → XP_037861057.1  histone-lysine N-methyltransferase 2A isoform X3

      UniProtKB/TrEMBL
      A0A0D9S3M1
      Conserved Domains (9) summary
      cd05493
      Location:1679 → 1809
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3701 → 3784
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1465 → 1511
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1513 → 1562
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1600 → 1656
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1903 → 2015
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1179 → 1226
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3848 → 4001
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2056 → 2103
      FYRN; F/Y-rich N-terminus

    5. XM_008021065.2 → XP_008019256.2  histone-lysine N-methyltransferase 2A isoform X1

      UniProtKB/TrEMBL
      A0A0D9S3M1
      Conserved Domains (9) summary
      cd05493
      Location:1682 → 1812
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3704 → 3787
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1465 → 1511
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1513 → 1562
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1600 → 1659
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1906 → 2018
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1179 → 1226
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3851 → 4004
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2059 → 2106
      FYRN; F/Y-rich N-terminus

    6. XM_038005131.1 → XP_037861059.1  histone-lysine N-methyltransferase 2A isoform X7

      UniProtKB/TrEMBL
      A0A0D9S3M1
      Conserved Domains (9) summary
      cd05493
      Location:811 → 941
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:2833 → 2916
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:594 → 640
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:642 → 691
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:729 → 788
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1035 → 1147
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:308 → 355
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:2980 → 3133
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:1188 → 1235
      FYRN; F/Y-rich N-terminus

    7. XM_038005130.1 → XP_037861058.1  histone-lysine N-methyltransferase 2A isoform X6

      UniProtKB/TrEMBL
      A0A0D9S3M1
      Conserved Domains (9) summary
      cd05493
      Location:844 → 974
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:2866 → 2949
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:627 → 673
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:675 → 724
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:762 → 821
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1068 → 1180
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:341 → 388
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3013 → 3166
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:1221 → 1268
      FYRN; F/Y-rich N-terminus
    Nucleotide Protein
    Heading Accession and Version

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