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    CHADL chondroadherin like [ Homo sapiens (human) ]

    Gene ID: 150356, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CHADLprovided by HGNC
    Official Full Name
    chondroadherin likeprovided by HGNC
    Primary source
    HGNC:HGNC:25165
    See related
    Ensembl:ENSG00000100399 MIM:616236; AllianceGenome:HGNC:25165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLRR4B
    Summary
    Enables collagen binding activity and collagen fibril binding activity. Involved in negative regulation of collagen fibril organization. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 3.6), prostate (RPKM 1.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CHADL in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (41229513..41240931, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (41702131..41715871, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41625517..41636935, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene EP300 antisense RNA 1 Neighboring gene leucine rich repeat containing 37 member A14, pseudogene Neighboring gene uncharacterized LOC646927 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41593165-41593664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41602160-41602660 Neighboring gene L3MBTL2 antisense RNA 1 Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41613805-41614502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41614503-41615199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41632734-41633322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41633323-41633911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41633912-41634500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41634501-41635088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41636538-41637038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41637039-41637539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41652381-41652924 Neighboring gene Ran GTPase activating protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41652925-41653468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41654013-41654555 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41660124-41660999 Neighboring gene microRNA 6889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41667991-41668491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19112 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41685594-41686193 Neighboring gene Sharpr-MPRA regulatory region 14092 Neighboring gene Sharpr-MPRA regulatory region 10804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13783 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41697637-41698138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41704361-41704862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41704863-41705362 Neighboring gene zinc finger CCCH-type containing 7B Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41720150-41720650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41756000-41756522

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Styrkarsdottir U, et al. Nat Genet, 2017 May. PMID 28319091
    2. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation. Tillgren V, et al. J Biol Chem, 2015 Jan 9. PMID 25451920, Free PMC Article
    3. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Barallobre-Barreiro J, et al. Circulation, 2012 Feb 14. PMID 22261194
    4. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. König R, et al. Cell, 2008 Oct 3. PMID 18854154, Free PMC Article
    5. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature, 2014 Jul 24. PMID 25056061, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement.
      Title: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.
    2. CHADL appears to have a negative regulatory role, possibly ensuring the formation of a stable extracellular matrix.
      Title: The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of chondroadherin-like (CHADL) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables collagen fibril binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix structural constituent conferring compression resistance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of collagen fibril organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chondroadherin-like protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138481.2 → NP_612490.1  chondroadherin-like protein precursor

      See identical proteins and their annotated locations for NP_612490.1

      Status: VALIDATED

      Source sequence(s)
      AL035681
      Consensus CDS
      CCDS46715.1
      UniProtKB/Swiss-Prot
      Q05CY2, Q4G0S0, Q5JY13, Q6NUI6, Q86XY1, Q96E60
      UniProtKB/TrEMBL
      H0Y4I5
      Related
      ENSP00000216241.9, ENST00000216241.14
      Conserved Domains (6) summary
      smart00013
      Location:395 → 429
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:675 → 723
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:424 → 603
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:427 → 450
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:643 → 676
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:160 → 218
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      41229513..41240931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      41702131..41715871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325156.1 → XP_054181131.1  chondroadherin-like protein isoform X1

      UniProtKB/TrEMBL
      H0Y4I5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NUI6.2 GenPept UniProtKB/Swiss-Prot:Q6NUI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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