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    Prkn parkin RBR E3 ubiquitin protein ligase [ Arvicola amphibius (Eurasian water vole) ]

    Gene ID: 119820894, updated on 21-Mar-2024

    Summary

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    Gene symbol
    Prkn
    Gene description
    parkin RBR E3 ubiquitin protein ligase
    See related
    EnsemblRapid:ENSAAPG00005018283
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Arvicola amphibius
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Arvicolinae; Arvicola
    Orthologs
    human mouse all
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    Genomic context

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    See Prkn in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    101 current mArvAmp1.2 (GCF_903992535.2) 8 NC_052054.1 (6627377..7775711)
    100 previous assembly mArvAmp1.1 (GCF_903992535.1) 8 NC_052054.1 (6627377..7775716)

    Chromosome 8 - NC_052054.1Genomic Context describing neighboring genes Neighboring gene parkin coregulated Neighboring gene 60S ribosomal protein L15-like Neighboring gene cytochrome c oxidase subunit 5B, mitochondrial-like Neighboring gene thymosin beta-10-like Neighboring gene 60S ribosomal protein L23a-like Neighboring gene 60S ribosomal protein L6-like Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene mitogen-activated protein kinase kinase kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase parkin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Arvicola amphibius Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mArvAmp1.2

    Genomic

    1. NC_052054.1 Reference mArvAmp1.2

      Range
      6627377..7775711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038339600.2 → XP_038195528.1  E3 ubiquitin-protein ligase parkin isoform X1

      Related
      ENSAAPP00005023524.2, ENSAAPT00005025832.2
      Conserved Domains (4) summary
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam01485
      Location:312 → 374
      IBR; IBR domain, a half RING-finger domain
      pfam17978
      Location:227 → 317
      zf-RING_14; RING/Ubox like zinc-binding domain
      cd21382
      Location:145 → 228
      RING0_parkin; RING finger-like zinc-binding domain 0 of parkin

    2. XM_038339601.2 → XP_038195529.1  E3 ubiquitin-protein ligase parkin isoform X2

      Related
      ENSAAPP00005023498.2, ENSAAPT00005025802.2
      Conserved Domains (4) summary
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam01485
      Location:312 → 374
      IBR; IBR domain, a half RING-finger domain
      pfam17978
      Location:227 → 317
      zf-RING_14; RING/Ubox like zinc-binding domain
      cd21382
      Location:145 → 228
      RING0_parkin; RING finger-like zinc-binding domain 0 of parkin

    3. XM_038339602.2 → XP_038195530.1  E3 ubiquitin-protein ligase parkin isoform X3

      Conserved Domains (4) summary
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam01485
      Location:311 → 373
      IBR; IBR domain, a half RING-finger domain
      pfam17978
      Location:226 → 316
      zf-RING_14; RING/Ubox like zinc-binding domain
      cd21382
      Location:144 → 227
      RING0_parkin; RING finger-like zinc-binding domain 0 of parkin

    4. XM_038339603.1 → XP_038195531.1  E3 ubiquitin-protein ligase parkin isoform X4

      Conserved Domains (3) summary
      cd01798
      Location:3 → 76
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      pfam17978
      Location:227 → 317
      zf-RING_14; RING/Ubox like zinc-binding domain
      cd21382
      Location:145 → 228
      RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
    Nucleotide Protein
    Heading Accession and Version

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