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    Spata19 spermatogenesis associated 19 [ Mus musculus (house mouse) ]

    Gene ID: 75469, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spata19provided by MGI
    Official Full Name
    spermatogenesis associated 19provided by MGI
    Primary source
    MGI:MGI:1922719
    See related
    Ensembl:ENSMUSG00000031991 AllianceGenome:MGI:1922719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    spergen-1; 1700001L23Rik
    Summary
    Involved in sperm mitochondrion organization. Located in mitochondrial outer membrane and sperm midpiece. Orthologous to human SPATA19 (spermatogenesis associated 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 181.3) See more
    Orthologs
    human all
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    Genomic context

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    See Spata19 in Genome Data Viewer
    Location:
    9 A4; 9 12.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (27308103..27313007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (27396807..27401711)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53501 Neighboring gene STARR-positive B cell enhancer mm9_chr9:27020677-27020977 Neighboring gene STARR-seq mESC enhancer starr_23621 Neighboring gene immunoglobulin superfamily, member 9B Neighboring gene STARR-seq mESC enhancer starr_23623 Neighboring gene predicted gene, 30791 Neighboring gene STARR-seq mESC enhancer starr_23625 Neighboring gene STARR-seq mESC enhancer starr_23626 Neighboring gene ADP-ribosylation factor-like 4A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Spata-19 new variant with expression beyond meiotic phase of mouse testis development. Nourashrafeddin S, et al. Rep Biochem Mol Biol, 2014 Apr. PMID 26989727, Free PMC Article
    2. Spata19 is critical for sperm mitochondrial function and male fertility. Mi Y, et al. Mol Reprod Dev, 2015 Nov. PMID 26265198
    3. Cloning and characterization of a mouse spergen-1 localized in sperm mitochondria. Matsuoka Y, et al. Int J Androl, 2004 Jun. PMID 15139970
    4. Isolation and expression analysis of the human testis-specific gene, SPERGEN-1, a spermatogenic cell-specific gene-1. Miyamoto T, et al. J Assist Reprod Genet, 2003 Feb. PMID 12688595, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 19, mitochondrial
    Names
    spermatogenic cell-specific gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305058.1 → NP_001291987.1  spermatogenesis-associated protein 19, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001291987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate 5' exons, uses an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC154374, AK005610
      Consensus CDS
      CCDS90524.1
      UniProtKB/TrEMBL
      A0A1L1SQQ1
      Related
      ENSMUSP00000149525.2, ENSMUST00000214287.2
      Conserved Domains (1) summary
      pfam15212
      Location:11 → 119
      SPATA19; Spermatogenesis-associated protein 19, mitochondrial

    2. NM_029299.3 → NP_083575.1  spermatogenesis-associated protein 19, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_083575.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154374, AK005610
      Consensus CDS
      CCDS22941.1
      UniProtKB/Swiss-Prot
      Q810M9, Q9DAQ9
      UniProtKB/TrEMBL
      I6ZYN5
      Related
      ENSMUSP00000034473.6, ENSMUST00000034473.7
      Conserved Domains (1) summary
      pfam15212
      Location:25 → 154
      SPATA19; Spermatogenesis-associated protein 19, mitochondrial

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      27308103..27313007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAQ9.1 GenPept UniProtKB/Swiss-Prot:Q9DAQ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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