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    meep meep [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 261663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    meepprovided by FlyBase
    Official Full Name
    meepprovided by FlyBase
    Primary source
    FLYBASE:FBgn0063667
    Locus tag
    Dmel_CG32335
    See related
    AllianceGenome:FB:FBgn0063667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE72485; CG32335; Dmel\CG32335
    Summary
    Enables hydrolase activity, acting on ester bonds. Involved in cellular response to glucose stimulus and positive regulation of insulin receptor signaling pathway. Predicted to be active in nucleus. Orthologous to human C11orf54 (chromosome 11 open reading frame 54). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See meep in Genome Data Viewer
    Location:
    61F3-61F3; 3-0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1201871..1203036, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1201871..1203036, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Lysozyme X Neighboring gene APPL-interacting protein 1 Neighboring gene multiple wing hairs Neighboring gene uncharacterized protein Neighboring gene Lysozyme B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Meep, a Novel Regulator of Insulin Signaling, Supports Development and Insulin Sensitivity via Maintenance of Protein Homeostasis in Drosophila melanogaster. Pereira MT, et al. G3 (Bethesda), 2020 Dec 3. PMID 32998936, Free PMC Article
    2. Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold. Manjasetty BA, et al. Protein Sci, 2006 Apr. PMID 16522806, Free PMC Article
    3. The microbiome stabilizes circadian rhythms in the gut. Zhang Y, et al. Proc Natl Acad Sci U S A, 2023 Jan 31. PMID 36689661, Free PMC Article
    4. Hematopoietic plasticity mapped in Drosophila and other insects. Hultmark D, et al. Elife, 2022 Aug 3. PMID 35920811, Free PMC Article
    5. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in triglyceride homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    meep
    Names
    CG32335-PB
    meep-PB
    NP_728575.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1201871..1203036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167858.4 → NP_728575.2  meep [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728575.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRI0, Q8SXQ8
      Conserved Domains (1) summary
      pfam08925
      Location:31 → 310
      DUF1907; Domain of Unknown Function (DUF1907)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXQ8 Q8SXQ8

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