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    NCK2 NCK adaptor protein 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 481319, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NCK2provided by VGNC
    Official Full Name
    NCK adaptor protein 2provided by VGNC
    Primary source
    VGNC:VGNC:43652
    See related
    Ensembl:ENSCAFG00845009565
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NCK2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (38434612..38590460, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (37509022..37661002, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (38636761..38787028, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (38166351..38316130, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (38443073..38594964, complement)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097687 Neighboring gene uncharacterized LOC111097688 Neighboring gene uncharacterized LOC106559419 Neighboring gene uncharacterized LOC111097690

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of PERK-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoplasmic protein NCK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      38434612..38590460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038680167.1 → XP_038536095.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    2. XM_038680166.1 → XP_038536094.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    3. XM_038680165.1 → XP_038536093.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    4. XM_038680168.1 → XP_038536096.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    5. XM_038680164.1 → XP_038536092.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Related
      ENSCAFP00845013099.1, ENSCAFT00845016842.1
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      38166351..38316130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038488915.1 → XP_038344843.1  cytoplasmic protein NCK2

      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    2. XM_038488914.1 → XP_038344842.1  cytoplasmic protein NCK2

      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    3. XM_038488913.1 → XP_038344841.1  cytoplasmic protein NCK2

      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    4. XM_038488916.1 → XP_038344844.1  cytoplasmic protein NCK2

      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    5. XM_038488912.1 → XP_038344840.1  cytoplasmic protein NCK2

      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      38443073..38594964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038614795.1 → XP_038470723.1  cytoplasmic protein NCK2

    2. XM_038614794.1 → XP_038470722.1  cytoplasmic protein NCK2

    3. XM_038614793.1 → XP_038470721.1  cytoplasmic protein NCK2

    4. XM_038614796.1 → XP_038470724.1  cytoplasmic protein NCK2

    5. XM_038614792.1 → XP_038470720.1  cytoplasmic protein NCK2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      38636761..38787028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038550884.1 → XP_038406812.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    2. XM_038550883.1 → XP_038406811.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    3. XM_038550882.1 → XP_038406810.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    4. XM_038550885.1 → XP_038406813.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    5. XM_038550881.1 → XP_038406809.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      37509022..37661002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038643581.1 → XP_038499509.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    2. XM_005625985.4 → XP_005626042.1  cytoplasmic protein NCK2

      See identical proteins and their annotated locations for XP_005626042.1

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    3. XM_038643566.1 → XP_038499494.1  cytoplasmic protein NCK2

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    4. XM_005625986.4 → XP_005626043.1  cytoplasmic protein NCK2

      See identical proteins and their annotated locations for XP_005626043.1

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    5. XM_005625984.4 → XP_005626041.1  cytoplasmic protein NCK2

      See identical proteins and their annotated locations for XP_005626041.1

      UniProtKB/TrEMBL
      A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
    Nucleotide Protein
    Heading Accession and Version

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