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    Dnm1l dynamin 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114114, updated on 14-Nov-2024

    Summary

    Official Symbol
    Dnm1lprovided by RGD
    Official Full Name
    dynamin 1-likeprovided by RGD
    Primary source
    RGD:620416
    See related
    EnsemblRapid:ENSRNOG00000001813 AllianceGenome:RGD:620416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DLP1; Drp1; Dnml1
    Summary
    Enables several functions, including BH2 domain binding activity; identical protein binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including positive regulation of cellular component organization; response to hypoxia; and synaptic vesicle recycling. Located in several cellular components, including Golgi membrane; clathrin-coated pit; and perinuclear region of cytoplasm. Is active in presynaptic endocytic zone membrane and synaptic vesicle membrane. Biomarker of chronic kidney disease; dental fluorosis; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 422.0), Heart (RPKM 370.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dnm1l in Genome Data Viewer
    Location:
    11q23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (98084049..98135663)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (84581216..84632382)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88830968..88882271)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 4 Neighboring gene ribosomal protein S27a, pseudogene 23 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene tyrosyl-tRNA synthetase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables clathrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular distribution of mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial fragmentation involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial fragmentation involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial membrane fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peroxisome fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein complex oligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to flavonoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypobaric hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle recycling via endosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    NOT part_of clathrin coat of trans-Golgi network vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion-derived vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic endocytic zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynamin-1-like protein
    Names
    C-terminal region
    N-terminal region
    dynamin-like protein 1
    dynamin-related protein 1
    NP_446107.2
    XP_038943816.1
    XP_038943817.1
    XP_038943818.1
    XP_038943819.1
    XP_038943820.1
    XP_038943821.1
    XP_038943822.1
    XP_038943823.1
    XP_038943824.1
    XP_038943825.1
    XP_038943826.1
    XP_038943827.1
    XP_038943828.1
    XP_038943829.1
    XP_063126304.1
    XP_063126305.1
    XP_063126306.1
    XP_063126307.1
    XP_063126308.1
    XP_063126309.1
    XP_063126310.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053655.3NP_446107.2  dynamin-1-like protein

      See identical proteins and their annotated locations for NP_446107.2

      Status: PROVISIONAL

      Source sequence(s)
      BC085843
      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Related
      ENSRNOP00000078603.2, ENSRNOT00000101129.2
      Conserved Domains (4) summary
      cd08771
      Location:23302
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:88709
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:227510
      Dynamin_M; Dynamin central region
      pfam02212
      Location:622710
      GED; Dynamin GTPase effector domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      98084049..98135663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087888.2XP_038943816.1  dynamin-1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Related
      ENSRNOP00000002478.6, ENSRNOT00000002478.9
      Conserved Domains (3) summary
      cd08771
      Location:23321
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:245529
      Dynamin_M; Dynamin central region
      pfam02212
      Location:667755
      GED; Dynamin GTPase effector domain
    2. XM_039087890.2XP_038943818.1  dynamin-1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Conserved Domains (4) summary
      cd08771
      Location:23321
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:245529
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656744
      GED; Dynamin GTPase effector domain
      NF033761
      Location:540652
      gliding_GltJ; adventurous gliding motility protein GltJ
    3. XM_039087894.2XP_038943822.1  dynamin-1-like protein isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Conserved Domains (3) summary
      cd08771
      Location:23321
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:245529
      Dynamin_M; Dynamin central region
      pfam02212
      Location:641729
      GED; Dynamin GTPase effector domain
    4. XM_039087897.2XP_038943825.1  dynamin-1-like protein isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Conserved Domains (3) summary
      cd08771
      Location:23321
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:245529
      Dynamin_M; Dynamin central region
      pfam02212
      Location:630718
      GED; Dynamin GTPase effector domain
    5. XM_039087891.2XP_038943819.1  dynamin-1-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Conserved Domains (3) summary
      cd08771
      Location:23308
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:232516
      Dynamin_M; Dynamin central region
      pfam02212
      Location:654742
      GED; Dynamin GTPase effector domain
    6. XM_063270234.1XP_063126304.1  dynamin-1-like protein isoform X7

    7. XM_039087898.2XP_038943826.1  dynamin-1-like protein isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Conserved Domains (3) summary
      cd08771
      Location:23308
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:232516
      Dynamin_M; Dynamin central region
      pfam02212
      Location:628716
      GED; Dynamin GTPase effector domain
    8. XM_063270235.1XP_063126305.1  dynamin-1-like protein isoform X14

    9. XM_039087889.2XP_038943817.1  dynamin-1-like protein isoform X2

      UniProtKB/Swiss-Prot
      O35303, O35318, O35319, O35320, O35321, O35322, O35323, Q5U2W1, Q792T7, Q9R234, Q9R277
      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Related
      ENSRNOP00000079426.1, ENSRNOT00000097906.2
      Conserved Domains (3) summary
      cd08771
      Location:23315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:239523
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661749
      GED; Dynamin GTPase effector domain
    10. XM_039087892.2XP_038943820.1  dynamin-1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Related
      ENSRNOP00000002482.7, ENSRNOT00000002482.9
      Conserved Domains (4) summary
      cd08771
      Location:23315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:239523
      Dynamin_M; Dynamin central region
      pfam02212
      Location:650738
      GED; Dynamin GTPase effector domain
      NF033761
      Location:534646
      gliding_GltJ; adventurous gliding motility protein GltJ
    11. XM_039087896.2XP_038943824.1  dynamin-1-like protein isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Conserved Domains (3) summary
      cd08771
      Location:23315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:239523
      Dynamin_M; Dynamin central region
      pfam02212
      Location:635723
      GED; Dynamin GTPase effector domain
    12. XM_039087899.2XP_038943827.1  dynamin-1-like protein isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Conserved Domains (3) summary
      cd08771
      Location:23315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:239523
      Dynamin_M; Dynamin central region
      pfam02212
      Location:624712
      GED; Dynamin GTPase effector domain
    13. XM_039087893.2XP_038943821.1  dynamin-1-like protein isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Related
      ENSRNOP00000110808.1, ENSRNOT00000172935.1
      Conserved Domains (3) summary
      cd08771
      Location:23302
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:226510
      Dynamin_M; Dynamin central region
      pfam02212
      Location:648736
      GED; Dynamin GTPase effector domain
    14. XM_039087895.2XP_038943823.1  dynamin-1-like protein isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZNF9, A0A8L2Q0G8
      Conserved Domains (4) summary
      cd08771
      Location:23302
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:226510
      Dynamin_M; Dynamin central region
      pfam02212
      Location:637725
      GED; Dynamin GTPase effector domain
      NF033761
      Location:521633
      gliding_GltJ; adventurous gliding motility protein GltJ
    15. XM_039087900.2XP_038943828.1  dynamin-1-like protein isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Related
      ENSRNOP00000002477.7, ENSRNOT00000002477.10
      Conserved Domains (3) summary
      cd08771
      Location:23302
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:226510
      Dynamin_M; Dynamin central region
      pfam02212
      Location:611699
      GED; Dynamin GTPase effector domain
    16. XM_063270236.1XP_063126306.1  dynamin-1-like protein isoform X16

    17. XM_039087901.2XP_038943829.1  dynamin-1-like protein isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZNF9
      Conserved Domains (3) summary
      cd08771
      Location:1153
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:77361
      Dynamin_M; Dynamin central region
      pfam02212
      Location:499587
      GED; Dynamin GTPase effector domain
    18. XM_063270237.1XP_063126307.1  dynamin-1-like protein isoform X17

    19. XM_063270238.1XP_063126308.1  dynamin-1-like protein isoform X18

    20. XM_063270240.1XP_063126310.1  dynamin-1-like protein isoform X19

    21. XM_063270239.1XP_063126309.1  dynamin-1-like protein isoform X19