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    socs5b suppressor of cytokine signaling 5b [ Pimephales promelas (fathead minnow) ]

    Gene ID: 120463988, updated on 11-Apr-2024

    Summary

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    Gene symbol
    socs5b
    Gene description
    suppressor of cytokine signaling 5b
    Locus tag
    F2P79_018868
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pimephales promelas
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Leuciscidae; Pogonichthyinae; Pimephales
    Orthologs
    zebrafish all
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    Genomic context

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    See socs5b in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    100 current EPA_FHM_2.0 (GCF_016745375.1) Unplaced Scaffold NW_024121655.1 (63543..82941)

    NW_024121655.1Genomic Context describing neighboring genes Neighboring gene protein kinase C epsilon type-like Neighboring gene PROP paired-like homeobox 1 Neighboring gene multiple coagulation factor deficiency 2, ER cargo receptor complex subunit Neighboring gene tetratricopeptide repeat domain 7A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024121655 Unplaced Scaffold Reference EPA_FHM_2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 5b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Pimephales promelas Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EPA_FHM_2.0 Primary Assembly

    Genomic

    1. NW_024121655.1 Reference EPA_FHM_2.0 Primary Assembly

      Range
      63543..82941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039653270.1 → XP_039509204.1  suppressor of cytokine signaling 5b

      Conserved Domains (3) summary
      cd03739
      Location:505 → 561
      SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
      pfam12610
      Location:139 → 195
      SOCS; Suppressor of cytokine signalling
      cl15255
      Location:396 → 496
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version

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