Cdk10 cyclin-dependent kinase 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdk10provided by RGD
Official Full Name: cyclin-dependent kinase 10provided by RGD
Primary source: RGD:1304851
See related: EnsemblRapid:ENSRNOG00000016088 AllianceGenome:RGD:1304851
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Kidney (RPKM 137.7), Adrenal (RPKM 136.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (68168040..68184923)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (51260012..51273009)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (56024903..56032610)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH141043 (e-PCR)
- UniSTS:223043

RH132209 (e-PCR)
- UniSTS:215492

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase 10

Names: cell division protein kinase 10; cyclin-dependent kinase (CDC2-like) 10

NP_001020893.2

EC 2.7.11.22

NP_001103406.1

EC 2.7.11.22

NP_001103407.1

EC 2.7.11.22

XP_038953809.1

EC 2.7.11.22

XP_038953810.1

EC 2.7.11.22

XP_038953811.1

EC 2.7.11.22

XP_038953813.1

EC 2.7.11.22

XP_038953814.1

EC 2.7.11.22

XP_063134227.1

EC 2.7.11.22

XP_063134228.1

EC 2.7.11.22

XP_063134229.1

EC 2.7.11.22

XP_063134230.1

EC 2.7.11.22

XP_063134231.1

EC 2.7.11.22

XP_063134232.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025722.2 → NP_001020893.2 cyclin-dependent kinase 10 isoform 3

Status: REVIEWED

Description

Transcript Variant: This minor variant (3) contains an alternate 5' end exon compared to transcript variant 1, and encodes a longer isoform (3) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

AI071224, BC098804

UniProtKB/Swiss-Prot

Q4KM47

UniProtKB/TrEMBL

F1LSV8

Related

ENSRNOP00000059465.1, ENSRNOT00000066552.5

Conserved Domains (1) summary

cd07845
Location:41 → 349

STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
NM_001109936.1 → NP_001103406.1 cyclin-dependent kinase 10 isoform 1

See identical proteins and their annotated locations for NP_001103406.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the most predominant transcript and encodes isoform 1.

Source sequence(s)

AI071224, BC098804, DN935585, DY320517

UniProtKB/TrEMBL

A6IZW7, A6IZW8, G3V814

Conserved Domains (1) summary

cd07845
Location:31 → 339

STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
NM_001109937.1 → NP_001103407.1 cyclin-dependent kinase 10 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a different donor splice site at the first exon compared to transcript variant 1, resulting in translation initiation from an in-frame, downstream AUG, and a shorter isoform (2) compared to isoform 1.

Source sequence(s)

AI071224, BC098804, DN932869

UniProtKB/Swiss-Prot

Q4KM47

Conserved Domains (1) summary

cd07845
Location:1 → 268

STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

68168040..68184923

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278161.1 → XP_063134231.1 cyclin-dependent kinase 10 isoform X7
XM_063278158.1 → XP_063134228.1 cyclin-dependent kinase 10 isoform X5
XM_063278160.1 → XP_063134230.1 cyclin-dependent kinase 10 isoform X6
XM_039097882.2 → XP_038953810.1 cyclin-dependent kinase 10 isoform X2

UniProtKB/TrEMBL

A6IZW7

Related

ENSRNOP00000021607.5, ENSRNOT00000021607.10

Conserved Domains (1) summary

cd07845
Location:31 → 374

STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
XM_039097885.2 → XP_038953813.1 cyclin-dependent kinase 10 isoform X5

UniProtKB/Swiss-Prot

Q4KM47

Conserved Domains (1) summary

cd07845
Location:1 → 303

STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
XM_039097881.2 → XP_038953809.1 cyclin-dependent kinase 10 isoform X1

UniProtKB/Swiss-Prot

Q4KM47

Conserved Domains (1) summary

cd07845
Location:41 → 384

STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
XM_063278159.1 → XP_063134229.1 cyclin-dependent kinase 10 isoform X5
XM_039097883.2 → XP_038953811.1 cyclin-dependent kinase 10 isoform X3

UniProtKB/Swiss-Prot

Q4KM47

Conserved Domains (1) summary

cd07845
Location:41 → 373

STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
XM_063278157.1 → XP_063134227.1 cyclin-dependent kinase 10 isoform X4
XM_039097886.2 → XP_038953814.1 cyclin-dependent kinase 10 isoform X5

UniProtKB/Swiss-Prot

Q4KM47

Conserved Domains (1) summary

cd07845
Location:1 → 303

STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
XM_063278162.1 → XP_063134232.1 cyclin-dependent kinase 10 isoform X8