Cd53 Cd53 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cd53provided by RGD
Full Name: Cd53 moleculeprovided by RGD
Primary source: RGD:2310
See related: EnsemblRapid:ENSRNOG00000017874 AllianceGenome:RGD:2310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OX44; Ox-44
Summary: Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Predicted to be involved in positive regulation of myoblast fusion and receptor clustering. Located in cell surface. Orthologous to human CD53 (CD53 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 575.9), Thymus (RPKM 230.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (197040369..197087925, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (194352139..194399668, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (209489279..209537098, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD53 may shift natural killer cell responses from effector functions towards a proliferation phase.
Title: The tetraspanin CD53 modulates responses from activating NK cell receptors, promoting LFA-1 activation and dampening NK cell effector functions.
First identification of a tetraspanin protein in mesangial cells. CD53 antigen delivers a signal that initiates DNA synthesis.
Title: Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells.
Ligation of CD53 triggers a survival response and reduces the number of cells that enter apoptosis. The CD53 antigen interactions might contribute to cell survival in poorly vascularized regions of the tumor mass.
Title: Apoptosis protection and survival signal by the CD53 tetraspanin antigen.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94570 (e-PCR)
- UniSTS:119818

D2Wox27 (e-PCR)
- UniSTS:118122

D2Arb17 (e-PCR), detects polymorphism
- UniSTS:227315

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth	NAS Non-traceable Author Statement more info	PubMed
NOT involved_in regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leukocyte surface antigen CD53

Names: CD53 antigen; cell surface glycoprotein CD53; leukocyte antigen MRC OX-44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012523.2 → NP_036655.1 leukocyte surface antigen CD53

See identical proteins and their annotated locations for NP_036655.1

Status: VALIDATED

Source sequence(s)

BC078900, JAXUCZ010000002

UniProtKB/Swiss-Prot

P24485

UniProtKB/TrEMBL

A6HUR6

Related

ENSRNOP00000024344.2, ENSRNOT00000024344.6

Conserved Domains (2) summary

cd03164
Location:104 → 186

CD53_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:9 → 210

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

197040369..197087925 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101709.2 → XP_038957637.1 leukocyte surface antigen CD53 isoform X1

Conserved Domains (1) summary

cl02781
Location:3 → 81

tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...