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    Phf24 PHD finger protein 24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500446, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phf24provided by RGD
    Official Full Name
    PHD finger protein 24provided by RGD
    Primary source
    RGD:1559864
    See related
    EnsemblRapid:ENSRNOG00000000129 AllianceGenome:RGD:1559864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559864
    Summary
    Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of pain; gamma-aminobutyric acid signaling pathway; and regulation of GABAergic synaptic transmission. Predicted to be active in glutamatergic synapse and synaptic vesicle membrane. Orthologous to human PHF24 (PHD finger protein 24). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 147.5) and Heart (RPKM 26.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phf24 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61939261..61966879)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57143428..57171054)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58359744..58387446)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene SPATA31 subfamily F member 1 Neighboring gene SPATA31 subfamily F member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B5 Neighboring gene SPATA31 subfamily G member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PHF24 is expressed in the inhibitory interneurons in rats. Numakura Y, et al. Exp Anim, 2021 Feb 6. PMID 33115988, Free PMC Article
    2. GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Gaillard S, et al. Neuron, 2014 Oct 1. PMID 25242222, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PHF24 is expressed in the inhibitory interneurons in rats.
      Title: PHF24 is expressed in the inhibitory interneurons in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 24
    Names
    Gai-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398835.1 → NP_001385764.1  PHD finger protein 24

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A292G0W2, A0A8I6GMB9
      Conserved Domains (1) summary
      pfam16744
      Location:127 → 198
      Zf_RING; KIAA1045 RING finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      61939261..61966879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238122.5 → XP_006238184.1  PHD finger protein 24 isoform X1

      See identical proteins and their annotated locations for XP_006238184.1

      UniProtKB/TrEMBL
      A0A292G0W2, A0A8I6GMB9
      Conserved Domains (1) summary
      pfam16744
      Location:127 → 198
      Zf_RING; KIAA1045 RING finger

    2. XM_063288220.1 → XP_063144290.1  PHD finger protein 24 isoform X1

      UniProtKB/TrEMBL
      A0A292G0W2, A0A8I6GMB9

    3. XM_063288223.1 → XP_063144293.1  PHD finger protein 24 isoform X3

      UniProtKB/TrEMBL
      A0A292G0W2, D3ZB78

    4. XM_006238123.5 → XP_006238185.1  PHD finger protein 24 isoform X1

      See identical proteins and their annotated locations for XP_006238185.1

      UniProtKB/TrEMBL
      A0A292G0W2, A0A8I6GMB9
      Conserved Domains (1) summary
      pfam16744
      Location:127 → 198
      Zf_RING; KIAA1045 RING finger

    5. XM_017593720.3 → XP_017449209.1  PHD finger protein 24 isoform X3

      UniProtKB/TrEMBL
      A0A292G0W2, D3ZB78
      Conserved Domains (1) summary
      pfam16744
      Location:90 → 161
      Zf_RING; KIAA1045 RING finger

    6. XM_063288222.1 → XP_063144292.1  PHD finger protein 24 isoform X3

      UniProtKB/TrEMBL
      A0A292G0W2, D3ZB78
      Related
      ENSRNOP00000000141.3, ENSRNOT00000000141.7

    7. XM_039110972.2 → XP_038966900.1  PHD finger protein 24 isoform X1

      UniProtKB/TrEMBL
      A0A292G0W2, A0A8I6GMB9
      Related
      ENSRNOP00000096981.1, ENSRNOT00000120097.2
      Conserved Domains (1) summary
      pfam16744
      Location:127 → 198
      Zf_RING; KIAA1045 RING finger

    8. XM_039110974.2 → XP_038966902.1  PHD finger protein 24 isoform X1

      UniProtKB/TrEMBL
      A0A292G0W2, A0A8I6GMB9
      Conserved Domains (1) summary
      pfam16744
      Location:127 → 198
      Zf_RING; KIAA1045 RING finger

    9. XM_039110975.2 → XP_038966903.1  PHD finger protein 24 isoform X3

      UniProtKB/TrEMBL
      A0A292G0W2, D3ZB78
      Conserved Domains (1) summary
      pfam16744
      Location:90 → 161
      Zf_RING; KIAA1045 RING finger

    10. XM_017593718.3 → XP_017449207.1  PHD finger protein 24 isoform X2

      UniProtKB/TrEMBL
      A0A292G0W2

    11. XM_006238121.5 → XP_006238183.1  PHD finger protein 24 isoform X1

      See identical proteins and their annotated locations for XP_006238183.1

      UniProtKB/TrEMBL
      A0A292G0W2, A0A8I6GMB9
      Conserved Domains (1) summary
      pfam16744
      Location:127 → 198
      Zf_RING; KIAA1045 RING finger

    12. XM_017593719.3 → XP_017449208.1  PHD finger protein 24 isoform X3

      UniProtKB/TrEMBL
      A0A292G0W2, D3ZB78
      Conserved Domains (1) summary
      pfam16744
      Location:90 → 161
      Zf_RING; KIAA1045 RING finger

    13. XM_063288224.1 → XP_063144294.1  PHD finger protein 24 isoform X4

      UniProtKB/TrEMBL
      A6IIZ3
    Nucleotide Protein Strain
    Heading Accession and Version

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