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    Parp6 poly (ADP-ribose) polymerase family, member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Parp6provided by RGD
    Official Full Name
    poly (ADP-ribose) polymerase family, member 6provided by RGD
    Primary source
    RGD:1310937
    See related
    EnsemblRapid:ENSRNOG00000011199 AllianceGenome:RGD:1310937
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310937
    Summary
    Predicted to enable NAD+-protein ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Involved in positive regulation of dendrite morphogenesis. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Orthologous to human PARP6 (poly(ADP-ribose) polymerase family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 168.0), Muscle (RPKM 109.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Parp6 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (68912393..68944904)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (60016594..60049108)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64439933..64472443)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 202 Neighboring gene hexosaminidase subunit alpha Neighboring gene CUGBP, Elav-like family member 6 Neighboring gene U4 spliceosomal RNA Neighboring gene pyruvate kinase M1/2 Neighboring gene GRAM domain containing 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis. Huang JY, et al. Sci Rep, 2016 Jan 4. PMID 26725726, Free PMC Article
    2. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, et al. Mol Cell, 2015 Jun 18. PMID 26091342
    3. Family-wide analysis of poly(ADP-ribose) polymerase activity. Vyas S, et al. Nat Commun, 2014 Jul 21. PMID 25043379, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+-protein-cysteine ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein auto-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein mono-ADP-ribosyltransferase PARP6
    Names
    poly [ADP-ribose] polymerase 6
    NP_001100298.1
    XP_006243253.2
    XP_008764454.1
    XP_008764455.1
    XP_038937032.1
    XP_038937033.1
    XP_063121204.1
    XP_063121205.1
    XP_063121206.1
    XP_063121207.1
    XP_063121208.1
    XP_063121209.1
    XP_063121210.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106828.1 → NP_001100298.1  protein mono-ADP-ribosyltransferase PARP6

      See identical proteins and their annotated locations for NP_001100298.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A6J529
      Conserved Domains (1) summary
      cd01341
      Location:470 → 594
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      68912393..68944904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081105.1 → XP_038937033.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

      UniProtKB/TrEMBL
      G3V9P8
      Conserved Domains (1) summary
      cd01341
      Location:471 → 595
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    2. XM_063265136.1 → XP_063121206.1  protein mono-ADP-ribosyltransferase PARP6 isoform X2

      UniProtKB/TrEMBL
      A6J529

    3. XM_006243191.2 → XP_006243253.2  protein mono-ADP-ribosyltransferase PARP6 isoform X1

      UniProtKB/TrEMBL
      G3V9P8
      Conserved Domains (1) summary
      cd01341
      Location:471 → 595
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    4. XM_008766232.3 → XP_008764454.1  protein mono-ADP-ribosyltransferase PARP6 isoform X3

      Conserved Domains (1) summary
      cd01341
      Location:451 → 575
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    5. XM_008766233.3 → XP_008764455.1  protein mono-ADP-ribosyltransferase PARP6 isoform X4

      Related
      ENSRNOP00000055141.5, ENSRNOT00000058339.5
      Conserved Domains (1) summary
      cd01341
      Location:450 → 574
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    6. XM_039081104.1 → XP_038937032.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

      UniProtKB/TrEMBL
      G3V9P8
      Conserved Domains (1) summary
      cd01341
      Location:471 → 595
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    7. XM_063265134.1 → XP_063121204.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

      UniProtKB/TrEMBL
      G3V9P8

    8. XM_063265137.1 → XP_063121207.1  protein mono-ADP-ribosyltransferase PARP6 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZUL8

    9. XM_063265138.1 → XP_063121208.1  protein mono-ADP-ribosyltransferase PARP6 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZUL8, A0A8I6GHS7

    10. XM_063265139.1 → XP_063121209.1  protein mono-ADP-ribosyltransferase PARP6 isoform X7

      UniProtKB/TrEMBL
      B2RZ49
      Related
      ENSRNOP00000094761.2, ENSRNOT00000119643.2

    11. XM_063265140.1 → XP_063121210.1  protein mono-ADP-ribosyltransferase PARP6 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZUL8, A0A8I6A4Q9
      Related
      ENSRNOP00000086132.2, ENSRNOT00000105803.2

    12. XM_063265135.1 → XP_063121205.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

      UniProtKB/TrEMBL
      G3V9P8
    Nucleotide Protein Strain
    Heading Accession and Version

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