Dixdc1 DIX domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dixdc1provided by RGD
Official Full Name: DIX domain containing 1provided by RGD
Primary source: RGD:1309902
See related: EnsemblRapid:ENSRNOG00000010260 AllianceGenome:RGD:1309902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccd1
Summary: Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in cerebellar cortex development; positive regulation of JNK cascade; and positive regulation of axonogenesis. Located in axon terminus and neuronal cell body. Part of protein-containing complex. Orthologous to human DIXDC1 (DIX domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 134.0), Liver (RPKM 56.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q23

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (59904218..59977595, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (51007835..51081191, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (55091232..55164636, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

up-regulation of Dixdc1 protein expression is potentially involved in astrocyte proliferation after traumatic brain injury in the rat.
Title: Expression of Dixdc1 and its Role in Astrocyte Proliferation after Traumatic Brain Injury.
these data demonstrated that Dixdc1 might participate in Schwann cell proliferation by targeting CyclinD1 and p21 at least partially through the PI3K/AKT activation.
Title: Dixdc1 targets CyclinD1 and p21 via PI3K pathway activation to promote Schwann cell proliferation after sciatic nerve crush.
findings define a novel SnoN-Ccd1 link that promotes axonal growth in the mammalian brain, with important implications for axonal development and regeneration
Title: A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain.
The DIX domain of rat axin, which is important for its homooligomerization and interactions with other regulators in the Wnt pathway, has been purified and crystallized.
Title: Crystallization and preliminary X-ray crystallographic studies of the axin DIX domain.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128680 (e-PCR)
- UniSTS:211988

RH137617 (e-PCR)
- UniSTS:219704

RH139711 (e-PCR)
- UniSTS:221795

RH139339 (e-PCR)
- UniSTS:221425

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables gamma-tubulin binding	IEA Inferred from Electronic Annotation more info
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables gamma-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase kinase kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell proliferation in forebrain	ISO Inferred from Sequence Orthology more info
involved_in cerebellar cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex cell migration	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex radially oriented cell migration	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex radially oriented cell migration	ISO Inferred from Sequence Orthology more info
involved_in forebrain ventricular zone progenitor cell division	IEA Inferred from Electronic Annotation more info
involved_in forebrain ventricular zone progenitor cell division	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
involved_in modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dixin

Names: DIX domain-containing protein 1; coiled-coil protein DIX1; coiled-coil-DIX1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395147.2 → NP_001382076.1 dixin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q2VUH7

UniProtKB/TrEMBL

A0A8L2QJF6

Related

ENSRNOP00000037500.6, ENSRNOT00000039045.7

Conserved Domains (3) summary

COG1196
Location:282 → 567

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd21213
Location:22 → 128

CH_DIXDC1; calponin homology (CH) domain found in Dixin and similar proteins

pfam00778
Location:602 → 678

DIX; DIX domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

59904218..59977595 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265745.1 → XP_063121815.1 dixin isoform X3

Related

ENSRNOP00000085938.2, ENSRNOT00000100212.2
XM_017595731.3 → XP_017451220.1 dixin isoform X2

UniProtKB/TrEMBL

A0A0G2K662

Related

ENSRNOP00000073690.3, ENSRNOT00000083102.3
XM_063265744.1 → XP_063121814.1 dixin isoform X2
XM_017595733.3 → XP_017451222.1 dixin isoform X5

UniProtKB/TrEMBL

A0A0G2K662

Conserved Domains (3) summary

COG1196
Location:202 → 487

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00778
Location:522 → 599

DIX; DIX domain

cl00030
Location:1 → 48

CH_SF; calponin homology (CH) domain superfamily
XM_063265746.1 → XP_063121816.1 dixin isoform X5
XM_017595732.3 → XP_017451221.1 dixin isoform X4

UniProtKB/TrEMBL

A0A8L2QJF6
XM_008766295.4 → XP_008764517.1 dixin isoform X1

UniProtKB/TrEMBL

A0A8L2QJF6

Conserved Domains (4) summary

cd00014
Location:22 → 138

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00778
Location:614 → 689

DIX; DIX domain

pfam02601
Location:383 → 472

Exonuc_VII_L; Exonuclease VII, large subunit

cl19219
Location:294 → 377

DUF342; Protein of unknown function (DUF342)
XM_008766296.3 → XP_008764518.1 dixin isoform X7

UniProtKB/TrEMBL

A6J4E9

Conserved Domains (3) summary

pfam00778
Location:391 → 466

DIX; DIX domain

pfam02601
Location:160 → 249

Exonuc_VII_L; Exonuclease VII, large subunit

cl19219
Location:71 → 154

DUF342; Protein of unknown function (DUF342)
XM_039081729.2 → XP_038937657.1 dixin isoform X6

UniProtKB/TrEMBL

A6J4E9

Conserved Domains (2) summary

COG1196
Location:85 → 370

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00778
Location:405 → 482

DIX; DIX domain
XM_039081730.2 → XP_038937658.1 dixin isoform X8

UniProtKB/TrEMBL

A6J4E9

Conserved Domains (2) summary

COG1196
Location:51 → 285

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00778
Location:320 → 397

DIX; DIX domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001037654.1: Suppressed sequence

Description

NM_001037654.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.