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    Cflar CASP8 and FADD-like apoptosis regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117279, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cflarprovided by RGD
    Official Full Name
    CASP8 and FADD-like apoptosis regulatorprovided by RGD
    Primary source
    RGD:620847
    See related
    EnsemblRapid:ENSRNOG00000012473 AllianceGenome:RGD:620847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Flip
    Summary
    Enables death receptor binding activity and protease binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell population proliferation; and positive regulation of cellular component organization. Part of CD95 death-inducing signaling complex. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 156.3), Lung (RPKM 134.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cflar in Genome Data Viewer
    Location:
    9q31
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67679502..67747226)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60185338..60236173)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65534608..65586395)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene BAF nuclear assembly factor 1, pseudogene 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene uncharacterized LOC100909946 Neighboring gene caspase 8 Neighboring gene uncharacterized LOC120094796 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene trafficking kinesin protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC108616

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables death receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nitric oxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in macrophage differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cellular response to transforming growth factor beta stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glomerular mesangial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of skeletal muscle satellite cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to testosterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in skeletal muscle atrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CD95 death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ripoptosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CASP8 and FADD-like apoptosis regulator

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033864.5NP_001029036.1  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_001029036.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      C0H5Y5, F7FBZ4
      Related
      ENSRNOP00000016730.3, ENSRNOT00000016730.7
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    2. NM_057138.3NP_476479.1  CASP8 and FADD-like apoptosis regulator isoform 2

      See identical proteins and their annotated locations for NP_476479.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      Q99MZ5
      Conserved Domains (2) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67679502..67747226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266581.1XP_063122651.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      C0H5Y5, F7FBZ4
    2. XM_039082962.2XP_038938890.1  CASP8 and FADD-like apoptosis regulator isoform X3

      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249268
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    3. XM_039082957.2XP_038938885.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      C0H5Y5, F7FBZ4
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    4. XM_006244949.5XP_006245011.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_006245011.1

      UniProtKB/TrEMBL
      C0H5Y5, F7FBZ4
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    5. XM_063266584.1XP_063122654.1  CASP8 and FADD-like apoptosis regulator isoform X3

    6. XM_063266582.1XP_063122652.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      C0H5Y5, F7FBZ4
    7. XM_039082958.2XP_038938886.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      C0H5Y5, F7FBZ4
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    8. XM_039082959.2XP_038938887.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      C0H5Y5, F7FBZ4
      Conserved Domains (3) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:249479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    9. XM_063266583.1XP_063122653.1  CASP8 and FADD-like apoptosis regulator isoform X2

    RNA

    1. XR_010054558.1 RNA Sequence

    2. XR_010054554.1 RNA Sequence

    3. XR_010054559.1 RNA Sequence

    4. XR_010054553.1 RNA Sequence

    5. XR_010054557.1 RNA Sequence

    6. XR_010054555.1 RNA Sequence

    7. XR_010054556.1 RNA Sequence

    8. XR_010054560.1 RNA Sequence