Nxnl1 nucleoredoxin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nxnl1provided by RGD
Full Name: nucleoredoxin-like 1provided by RGD
Primary source: RGD:1308296
See related: AllianceGenome:RGD:1308296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Txnl6
Summary: Predicted to be involved in photoreceptor cell maintenance. Orthologous to human NXNL1 (nucleoredoxin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 13.2), Adrenal (RPKM 10.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18303454..18311510, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18270604..18279797, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (19992211..19996815, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that daily regulation of Nxnl1 is driven by a circadian clock in the retina and pineal gland of rats.
Title: Transcriptional regulation of nucleoredoxin-like genes takes place on a daily basis in the retina and pineal gland of rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoredoxin-like protein 1

Names: thioredoxin-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271341.2 → NP_001258270.1 nucleoredoxin-like protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2K4X6

Conserved Domains (1) summary

cd03008
Location:8 → 153

TryX_like_RdCVF; Tryparedoxin (TryX)-like family, Rod-derived cone viability factor (RdCVF) subfamily; RdCVF is a thioredoxin (TRX)-like protein specifically expressed in photoreceptors. RdCVF was isolated and identified as a factor that supports cone survival in retinal ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

18303454..18311510 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094485.2 → XP_038950413.1 nucleoredoxin-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K4X6

Conserved Domains (1) summary

cd03008
Location:8 → 153

TryX_like_RdCVF; Tryparedoxin (TryX)-like family, Rod-derived cone viability factor (RdCVF) subfamily; RdCVF is a thioredoxin (TRX)-like protein specifically expressed in photoreceptors. RdCVF was isolated and identified as a factor that supports cone survival in retinal ...

RNA

XR_001841535.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107302.2: Suppressed sequence

Description

NM_001107302.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.