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    madd-3 Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3 [ Caenorhabditis elegans ]

    Gene ID: 3565068, updated on 9-Dec-2024

    Summary

    Official Symbol
    madd-3
    Official Full Name
    Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3
    Primary source
    WormBase:WBGene00006517
    Locus tag
    CELE_E02H4.3
    See related
    AllianceGenome:WB:WBGene00006517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; and vulval muscle. Orthologous to several human genes including CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See madd-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (14284752..14296659, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Amiloride-sensitive sodium channel subunit alpha;Degenerin del-1 Neighboring gene ncRNA Neighboring gene MIF4G domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein tyrosine kinase activity  
    Process Evidence Code Pubs
    involved_in protein phosphorylation  
    involved_in regulation of RNA splicing  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3
    NP_001355370.1
    • Confirmed by transcript evidence
    NP_001355453.1
    • Confirmed by transcript evidence
    NP_001368709.1
    • Partially confirmed by transcript evidence
    NP_001380238.1
    • Confirmed by transcript evidence
    NP_001380239.1
    • Confirmed by transcript evidence
    NP_741928.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14284752..14296659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171799.8 → NP_741928.1  putative dual specificity protein kinase madd-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDB2, G5EGK0
      Conserved Domains (2) summary
      cd14134
      Location:538 → 863
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
      cl26464
      Location:73 → 364
      Atrophin-1; Atrophin-1 family
    2. NM_001392883.1 → NP_001380239.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E026
      Conserved Domains (1) summary
      cd14134
      Location:1 → 248
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    3. NM_001368550.4 → NP_001355370.1  putative dual specificity protein kinase madd-3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14134
      Location:244 → 572
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    4. NM_001392884.1 → NP_001380238.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E4Y4
      Conserved Domains (1) summary
      cd14134
      Location:1 → 251
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    5. NM_001368549.4 → NP_001355453.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1DR12
      Conserved Domains (1) summary
      cd14134
      Location:244 → 569
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    6. NM_001381143.1 → NP_001368709.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E657
      Conserved Domains (2) summary
      PHA03247
      Location:73 → 364
      PHA03247; large tegument protein UL36; Provisional
      cd14134
      Location:538 → 866
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
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