CG14207 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG14207provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0031037
Locus tag: Dmel_CG14207
See related: AllianceGenome:FB:FBgn0031037
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: dHspB8; Dmel21.3; Dmel\CG14207; Hsp20; Hsp20-like protein; HspB8
Summary: Predicted to enable unfolded protein binding activity. Involved in protein refolding. Located in Z disc. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; larval muscle cell; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18D3-18D3; 1-63 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19605199..19611413)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19499232..19505446)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila, including CG14207
Title: The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	ISM Inferred from Sequence Model more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG14207-PA; CG14207-PB; CG14207-PC; CG14207-PD; HspB8; small heat shock protein hsp20 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19605199..19611413

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298517.1 → NP_001285446.1 uncharacterized protein Dmel_CG14207, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285446.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VWG1

Conserved Domains (1) summary

cd06526
Location:87 → 168

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
NM_167669.3 → NP_728275.1 uncharacterized protein Dmel_CG14207, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728275.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQW5

Related

FBpp0074503

Conserved Domains (1) summary

cd06526
Location:96 → 177

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
NM_134482.4 → NP_608326.1 uncharacterized protein Dmel_CG14207, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608326.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VWG1

Related

FBpp0074502

Conserved Domains (1) summary

cd06526
Location:87 → 168

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
NM_001258831.1 → NP_001245760.1 uncharacterized protein Dmel_CG14207, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245760.1

Status: REVIEWED

UniProtKB/TrEMBL

D2NUF4, M9NHC5

Conserved Domains (1) summary

cd06526
Location:58 → 139

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...