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    Pif1 Pif1 DNA helicase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pif1provided by FlyBase
    Official Full Name
    Pif1 DNA helicaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031540
    Locus tag
    Dmel_CG3238
    See related
    AllianceGenome:FB:FBgn0031540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3238; Dmel\CG3238; pif1
    Summary
    Predicted to enable 5'-3' DNA helicase activity. Involved in double-strand break repair via break-induced replication. Predicted to be active in replication fork. Is expressed in organism. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pif1 in Genome Data Viewer
    Location:
    23F3-23F3; 2-10 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3467342..3470004, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3467342..3470004, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene male-specific lethal 2 Neighboring gene mir-4971 stem loop Neighboring gene NADH dehydrogenase (ubiquinone) PDSW subunit Neighboring gene uncharacterized protein Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Homolog-Dependent Repair Following Dicentric Chromosome Breakage in Drosophila melanogaster. Bhandari J, et al. Genetics, 2019 Jul. PMID 31053594, Free PMC Article
    2. Molecular underpinnings and environmental drivers of loss of heterozygosity in Drosophila intestinal stem cells. Al Zouabi L, et al. Cell Rep, 2023 Dec 26. PMID 38032794
    3. The Drosophila melanogaster PIF1 Helicase Promotes Survival During Replication Stress and Processive DNA Synthesis During Double-Strand Gap Repair. Kocak E, et al. Genetics, 2019 Nov. PMID 31537623, Free PMC Article
    4. Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase γ by Organization of the Template DNA. Ciesielski GL, et al. J Biol Chem, 2015 Nov 27. PMID 26446790, Free PMC Article
    5. Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells. Alexander JL, et al. Proc Natl Acad Sci U S A, 2016 Nov 29. PMID 27849606, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila PIF1 functions with POL32 during times of replication stress but acts independently of POL32 to promote synthesis during double-strand gap repair.
      Title: The Drosophila melanogaster PIF1 Helicase Promotes Survival During Replication Stress and Processive DNA Synthesis During Double-Strand Gap Repair.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Pif1 DNA helicase
    Names
    CG3238-PA
    CG3238-PB
    Pif1 helicase
    Pif1 ortholog
    Pif1-PA
    Pif1-PB
    NP_001285587.1
    NP_608782.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3467342..3470004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298658.1 → NP_001285587.1  Pif1 DNA helicase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQR3
      Conserved Domains (1) summary
      cl21455
      Location:205 → 510
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_134938.3 → NP_608782.1  Pif1 DNA helicase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQR3
      Related
      FBpp0077258
      Conserved Domains (1) summary
      cl21455
      Location:205 → 510
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQR3 Q9VQR3

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