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    CG4364 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4364provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032138
    Locus tag
    Dmel_CG4364
    See related
    AllianceGenome:FB:FBgn0032138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4364
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; mesoderm; and posterior endoderm. Orthologous to human PES1 (pescadillo ribosomal biogenesis factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4364 in Genome Data Viewer
    Location:
    30C5-30C6; 2-36 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9708921..9711271, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9708921..9711271, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hoi-polloi Neighboring gene uncharacterized protein Neighboring gene pelota Neighboring gene Nckx30C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Demontis F, et al. Cell Rep, 2014 Jun 12. PMID 24882005, Free PMC Article
    2. Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes. Hulf T, et al. Mol Cell Biol, 2005 May. PMID 15831447, Free PMC Article
    3. Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis. Pulianmackal AJ, et al. Dis Model Mech, 2022 Mar 1. PMID 35107131, Free PMC Article
    4. Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis. Fouix S, et al. Genes Cells, 2003 Nov. PMID 14622141
    5. Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Demontis F, et al. Development, 2009 Mar. PMID 19211682, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PeBoW complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4364-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9708921..9711271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135461.4 → NP_609305.1  uncharacterized protein Dmel_CG4364 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609305.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VL96
      Related
      FBpp0079445
      Conserved Domains (3) summary
      COG5163
      Location:1 → 601
      NOP7; Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]
      pfam06732
      Location:7 → 268
      Pescadillo_N; Pescadillo N-terminus
      pfam16589
      Location:323 → 413
      BRCT_2; BRCT domain, a BRCA1 C-terminus domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL96.1 Q9VL96

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